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EC number: 266-737-7 | CAS number: 67584-59-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Fate of C4 sulfonamido methacrylate is addressed by a mixture of experimental data, calculation, and readacross of data from C4 acrylate. The Target chemical and the Source chemical both contain the nonafluorobutylsulfon-N-methylamidoethoxyl (i.e., C4 sulfonamido alcohol) functionality. The Target chemical contains this structure esterified with methacrylic acid. The Source chemical contains the same group esterified with acrylic acid. The Source chemical and the Target chemical have similar molecular weight. Water solubility differs between the two chemicals by approximately a factor of ten, while octanol-water partition coefficient differs by less than one log unit. Acrylate and methacrylate functionalities are electrophilic and both may participate in Michael addition reactions. Metabolism occurs through the same pathways, hydrolysis by carboxylesterases and conjugation to gluthathione. Hydrolysis is similar across the acrylate family and enhances the elimination of the chemical upon exposure (McCarthy & Witz (1997), Toxicol. 116, 153). Enzymatic hydrolysis kinetic constants for methacrylate and acrylate esters are similar. Because the source and target substances exhibit similarity in their structures physicochemical properties and metabolic properties, data gaps for biodegradation can be addressed by read across. C4 acrylate was not readily biodegradable in a test conducted under test guideline OECD301B. C4 sulfonamido methacrylate is also expected not to be readily biodegradable, but instead to be persistent in the environment. The reason for lack of biodegradation is not clear given the extensive in vivo hydrolysis observed in toxicokinetic studies of both C4 acrylate and C4 sulfonamido methacrylate. C4 acrylate showed no toxicity to microorganisms in an OECD 209 study, and C4 sulfonamido methacrylate is similarly expected. Had hydrolysis occurred during the 301B test, the resulting acrylic acid would have been metabolized easily to carbon dioxide and detected. Abiotic hydrolysis results are also read across from C4 acrylate. C4 sulfonamido methacrylate is expected to have hydrolysis half-lives of 0.6049 years at pH 7 and 25°C, 15.14 years at pH 4 and 25 °C, and 1.608 years at pH 9 and 25 °C. Owing to extensive water treatment technologies at the production facility, neither biodegradation nor abiotic hydrolysis are expected to have a significant impact on fate. Larger releases are expected to the air compartment. A modeled rate constant of 3.19E-011 cm³/molecule∙s for reaction with hydroxyl radical indicates a projected atmospheric half-life of 12 hours for C4 sulfonamido methacrylate.
C4 sulfonamido methacrylate has a measured log Kow of 4.68. However, owing to extensive in vivo metabolism in the toxicokinetic studies, no bioaccumulation is expected. The metabolic products are themselves far more hydrophilic than the parent and are also not expected to be subject to bioaccumulation.
C4 sulfonamido methacrylate has an organic carbon normalized soil:water adsorption coefficient of 11,500 L/kg calculated from the log Kow. It is expected to sorb to surfaces.
Please see Analogue Reporting Format, IUCLID Section 13, for further information justifying the readacross.
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