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EC number: 200-309-2 | CAS number: 57-06-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2002
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Sensitization and Desensitization to Allyl Isothiocyanate (Mustard Oil) in the Nasal Cavity
- Author:
- Gerard Brand and Laurence Jacquot
- Year:
- 2 002
- Bibliographic source:
- Chem. Senses 27: 593–598, 2002
Materials and methods
- Type of sensitisation studied:
- respiratory
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Sixty subjects participated in the experiment, which employed psychophysical (intensity ratings) and psychophysiological (skin conductance response) measurements. Nasal stimuli were delivered three times with different inter-stimulus intervals.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Allyl isothiocyanate
- EC Number:
- 200-309-2
- EC Name:
- Allyl isothiocyanate
- Cas Number:
- 57-06-7
- Molecular formula:
- C4H5NS
- IUPAC Name:
- 3-isothiocyanatoprop-1-ene
- Test material form:
- liquid
Constituent 1
Method
- Type of population:
- other: students
- Ethical approval:
- not specified
- Subjects:
- 60 Female volunteer students participated in this experiment. Their ages ranged from 19 to 27 years (mean age 23 years 5 months). All subjects were dextrals, non-smokers and reported normal smell and taste sensitivity.
- Clinical history:
- None of the subjects had a history of nasal/sinus disease or extensive exposure to chemicals with potential olfactory or trigeminal toxicity.
- Route of administration:
- inhalation
- Details on study design:
- The nasal stimulus was allyl isothiocyanate diluted in mineral oil. The concentration used was 25%, in a suprathreshold higher than the standardized detection thresholds (Devos et al., 1990). The nasal stimulus in liquid form was presented in a bottle filled with 4 ml of liquid. The bottle was presented three times to the subject during a limited period of 2 s (one inspiration) at a distance of 1 cm from both nostrils using a holder to avoid any olfactory or thermic interference from the experimenter’s hand.
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The results showed that the psychophysical and psychophysiological data were correlated and that the successive nasal stimuli after a short period of time (<2 min) produced increased intensity of irritation, whereas the stimuli delivered after >3 min produced a markedly decreased intensity of irritation. These findings are in agreement with those obtained with capsaicin, the most frequently used irritant molecule.
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