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EC number: 269-634-5 | CAS number: 68308-19-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-05-30 to 2018-08-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- Three vessels were set up in a parallel design, each vessel was sampled several times instead of sampling one vessel at every point in time/ exclusion of O2 and CO2, under inert gas (argon)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- yes
- Remarks:
- Three vessels were set up in a parallel design, each vessel was sampled several times instead of sampling one vessel at every point in time/ exclusion of O2 and CO2, under inert gas (argon)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed, 2019-07-15 (inspection date: 2018-10-25)
- Type of method:
- flask method
- Specific details on test material used for the study:
- Appearance: solid, highly viscous, sticky, green
Storage conditions: Keep container tightly closed, in a dry place at room temperature - Key result
- Water solubility:
- 53.1 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 574.5 mg/L
- Incubation duration:
- 34 d
- Temp.:
- 20 °C
- pH:
- >= 6.07 - <= 6.14
- Remarks on result:
- other: S.D: ± 6.1 mg/L
- Remarks:
- Calculated on a mean dissolved copper concentration of 5.84 ± 0.67 mg/L and a copper content of 11 %.
- Water solubility:
- 5.84 mg/L
- Conc. based on:
- element (dissolved fraction)
- Remarks:
- Cu
- Loading of aqueous phase:
- 574.5 other: mg test item /L
- Incubation duration:
- 34 d
- Temp.:
- 20 °C
- pH:
- >= 6.07 - <= 6.14
- Remarks on result:
- other: S.D: ± 0.76 mg/L
- Details on results:
- Observations
- 1st test: a resinous substance sticked at the sample boats until day 10. Then the undissolved material was extensively dispersed inside the vessel.
- 2nd test: an undissolved substance is located at the bottom of the test item loaded vessels mostly in the middle.
Temperature: The mean temperature was 19.0 ± 0.2 °C in the 1st and 20.0 ± 0.4 °C in the 2nd test.
Oxygen: no oxygen was detectable in both tests
pH:
- 1st test: test item solutions: 5.5 – 6.8; method blanks: 6.4 – 7.3.
- 2nd test: test item solutions: 4.9 – 6.6; method blanks: 6.7 – 7.8.
Turbidity: In both tests were always <1 NTU indicating that filtered solutions did not contain any undissolved material. - Conclusions:
- Under the conditions of the test (under exclusion of CO2 and O2, under inert gas; flask method; loadings of 430.8, 425.3 and 522.7 mg/L test substance in three replicate test vessels, a solubility equilibrium was not observed during testing. However, the dissolved copper concentration analysed on day 34 of testing is 5.84 ± 0.67 mg/L (determined as dissolved copper, separated by filtration from undissolved test item) at 20.0 ± 0.4 °C This corresponds to a water solubility of “fatty acids, C6-19-branched, copper salts” of 53.1 ± 6.1 mg/L, calculated on a copper content of 11.0 %.
The pH of solutions containing the test item ranged between 4.9 – 6.6. The pH in method blanks remained in the range of 6.1 – 7.8.
Reference
ICP-OES measurement with corresponding LOD/LOQ, correlation coefficient and sum of quality assurance samples and recovery (2nd test).
Calibration [µg/L] – lowest and highest calibration point |
Chosen wavelength [nm] |
LOD |
LOQ |
Correlation coefficient |
Sum of quality assurance samples |
Recovery / validity of quality assurance samples [%] |
July 02, 2018 measurement of samples from d3 |
||||||
1 – 1000 (total of 13 calibration points, 12 used + blank) |
219.227 |
0.748 |
2.24 |
0.999947 |
13 |
100 |
July 03, 2018 measurement of samples from d4 |
||||||
1 – 1000 (total of 13 calibration points, 13 used + blank) |
224.700 |
1.65 |
4.94 |
0.999945 |
13 |
100 |
July 04, 2018 measurement of samples from d5 |
||||||
1 – 1000 (total of 13 calibration points, 12 used + blank) |
219.227 |
0.538 |
1.61 |
0.999986 |
13 |
100 |
July 10, 2018 measurement of samples from d11 |
||||||
2.5 – 1000 (total of 13 calibration points, 12 used + blank) |
224.700 |
1.86 |
5.59 |
0.999986 |
13 |
100 |
July 11, 2018 measurement of samples from d12 |
||||||
2.5 – 1000 (total of 13 calibration points, 12 used + blank) |
224.700 |
1.68 |
5.03 |
0.999978 |
13 |
100 |
July 12, 2018 measurement of samples from d13 |
||||||
1 – 1000 (total of 13 calibration points, 12 used + blank) |
219.227 |
2.83 |
8.49 |
0.999986 |
13 |
100 |
July 17, 2018 measurement of samples from d13 |
||||||
1 – 1000 (total of 13 calibration points, 13 used + blank) |
224.700 |
1.02 |
3.05 |
0.999981 |
13 |
100 |
July 18, 2018 measurement of samples from d19 |
||||||
2.5 – 750 (total of 12 calibration points, 11 used + blank) |
223.009 |
3.55 |
10.6 |
0.999965 |
13 |
100 |
July 19, 2018 measurement of samples from d20 |
||||||
1 – 1000 (total of 13 calibration points, 12 used + blank) |
224.700 |
0.665 |
1.99 |
0.999975 |
13 |
100 |
July 31, 2018 measurement of samples from d32 |
||||||
25 – 1000 (total of 13 calibration points, 8 used + blank) |
217.895 |
2.31 |
6.93 |
0.999994 |
21 |
100 |
August 01, 2018 measurement of samples from d33 |
||||||
2.5 – 1000 (total of 13 calibration points, 12 used + blank) |
224.700 |
0.913 |
2.74 |
0.999989 |
21 |
100 |
August 02, 2018 measurement of samples from d34 |
||||||
1 – 1000 (total of 13 calibration points, 13 used + blank) |
224.700 |
0.535 |
1.61 |
0.999964 |
21 |
100 |
August 03, 2018 measurement of samples from d35 |
||||||
1 – 1000 (total of 13 calibration points, 13 used + blank) |
224.700 |
0.204 |
0.611 |
0.999945 |
13 |
100 |
Recovery/validation data copper of the 2nd test
Date |
Recovery [%] ± SD [%] (n total/ n valid) |
||||
Recalibration standard 50 µg/L |
Recalibration standard 500 µg/L |
Quality control standard (Roth) 100 µg/L |
TMDA-70.2 nominal value 406 µg/L diluted 2-fold nominal value 203 µg/L |
Quality control standard (Roth) 750 µg/L |
|
July 02, 2018 |
95.2 ± 2.2 (3/3) |
|
106 ± 1 (3/3) |
103 ±1 (3/3) |
103 ± 1 (3/3) |
July 03, 2018 |
100 ± 1 (3/3) |
|
106 ± 1 (3/3) |
103 ± 1 (3/3) |
103 ± 1 (3/3) |
July 03, 2018 |
99.2 ± 1.0 (3/3) |
|
106 ± <1 (3/3) |
104 ± 1 (3/3) |
103 ± <1 (3/3) |
July 10, 2018 |
96.8 ± 0.4 (3/3) |
|
103 ± 1 (3/3) |
102 ± <1 (3/3) |
101 ± <1 (3/3) |
July 11, 2018 |
98.9 ± 0.8 (3/3) |
|
103 ± 1 (3/3) |
101 ± 1 (3/3) |
101 ± 1 (3/3) |
July 12, 2018 |
97.1 ± 0.9 (3/3) |
|
103 ± 1 (3/3) |
101 ± 2 (3/3) |
102 ± <1 (3/3) |
July 17, 2018 |
|
98.9 ± 0.9 (3/3) |
104 ± 2 (3/3) |
101 ± <1 (3/3) |
101 ± 1 (3/3) |
July 18, 2018 |
|
99.0 ± 0.6 (3/3) |
107 ± <1 (3/3) |
104 ± 1 (3/3) |
102 ± <1 (3/3) |
July 19, 2018 |
|
98.3 ± 0.6 (4/4) |
103 ± 1 (4/4) |
101 ± 1 (4/4) |
101 ± 1 (4/4) |
July 31, 2018 |
|
97.4 ± 0.9 (5/5) |
102 ± 1 (5/5) |
101 ± 2 (5/5) |
99.6 ± 0.4 (5/5) |
August 01, 2018 |
|
100 ± 1 (5/5) |
103 ± 1 (5/5) |
105 ± 1 (5/5) |
102 ± <1 (5/5) |
August 02, 2018 |
|
99.3 ± 1.5 (5/5) |
103 ± 2 (5/5) |
102 ± <1 (5/5) |
102 ± 2 (5/5) |
August 03, 2018 |
|
98.8 ± 0.8 (3/3) |
103 ± 1 (3/3) |
101 ± 1 (3/3) |
101 ± 1 (3/3) |
A selected sample was fortified with a known amount of copper (by standard addition of commercial standard) to determine the standard recovery of this element.
Cu fortification: Measurement series from the 2nd test
Sample / Date |
Measured concentration [µg/L] |
Calculated level after addition [µg/L] |
Recovery [µg/L] / [%] |
July 02, 2018 |
|||
Vessel 1 sample a 3d sampling; dilution 10-fold; 1 mL sample + 4 mL 100 µg/L standard |
255 |
131 |
132 / 101 |
July 03, 2018 |
|||
Vessel 1 sample a 4d sampling; dilution 10-fold; 1 mL sample + 4 mL 100 µg/L standard |
266 |
133 |
141 / 106 |
July 04, 2018 |
|||
Vessel 1 sample a 5d sampling; dilution 10-fold; 1 mL sample + 4 mL 100 µg/L standard |
278 |
136 |
136 / 100 |
July 10, 2018 |
|||
Vessel 1 sample a 11d sampling; dilution 10-fold; 1 mL sample + 4 mL 100 µg/L standard |
330 |
146 |
146 / 99.7 |
July 11, 2018 |
|||
Vessel 1 sample a 12d sampling; dilution 10-fold; 1 mL sample + 4 mL 100 µg/L standard |
331 |
146 |
146 / 99.7 |
July 12, 2018 |
|||
Vessel 1 sample a 13d sampling; dilution 10-fold; 1 mL sample + 4 mL 100 µg/L standard |
345 |
149 |
148 / 99.4 |
July 17, 2018 |
|||
Vessel 1 sample a 13d sampling; dilution 10-fold; 1 mL sample + 4 mL 100 µg/L standard |
377 |
155 |
155 / 99.4 |
July 18, 2018 |
|||
Vessel 1 sample a 19d sampling; dilution 10-fold; 1 mL sample + 4 mL 100 µg/L standard |
395 |
159 |
154 / 97.0 |
July 19, 2018 |
|||
Vessel 1 sample a 20d sampling; dilution 10-fold; 1 mL sample + 4 mL 100 µg/L standard |
400 |
160 |
162 / 101 |
July 31, 2018 |
|||
Vessel 1 sample a 32d sampling; dilution 10-fold; 1 mL sample + 4 mL 100 µg/L standard |
514 |
183 |
181 / 98.9 |
August 01, 2018 |
|||
Vessel 1 sample a 33d sampling; dilution 10-fold; 1 mL sample + 4 mL 100 µg/L standard |
555 |
191 |
193 / 101 |
August 02, 2018 |
|||
Vessel 1 sample a 34d sampling; dilution 10-fold; 1 mL sample + 4 mL 100 µg/L standard |
534 |
187 |
190 / 102 |
August 03, 2018 |
|||
Vessel 1 sample a 35d sampling; dilution 10-fold; 1 mL sample + 4 mL 100 µg/L standard |
559 |
192 |
196 / 102 |
Results:
1st test
Background copper levels of method blanks remained ≤ 5 µg Cu/L during the whole test. A background correction was not considered relevant, since copper concentrations of solutions containing the test item are at least 650 times higher.
The variation between the sampling days for the copper concentration measured was less than 15 % for the days 2, 3, 10, 11, 15 and 16. Thus, the validity criteria were fulfilled. However, since the relative standard deviation of analysed copper content between the two replicate test vessels after 3 days of testing varies between 13.3 % and 39.7 % and a slight increase of the copper concentration was observed till test day 17, the test was repeated.
2nd test
Background copper levels of method blanks remained ≤ 11 µg Cu/L during the whole test. A background correction was not considered relevant, since copper concentrations of solutions containing the test item are at least 200 times higher.
The variation between the sampling days for the copper concentration measured was less than 15 % for at least the days 33 and 34. Hence, the test is considered as fully reliable. Nevertheless, the copper concentration in vessel 2 on day 35 increases significantly. This may be due to the low remaining test item solution. Hence, as proposed by the study monitor, values of day 35 of testing were neglected. Since, the values in the three replicate test vessels slightly increases (< 15 % as described above) during the test period of 35 days and based on the low remaining test item solution on day 35, the copper concentration analysed on day 34 was used to report the water solubility of the test item. There is still no solubility equilibrium reached till day 35 of testing. However, the water solubility of “fatty acids, C6-19-branched, copper salts“ on day 34 is 53.1 ± 6.1 mg/L, based on a mean copper concentration of 5.84 ± 0.67 mg Cu/L analysed via ICP-OES and a copper content of 11 % in test item.
Mean Cu concentrations:
Vessel 1: 5.39 ± 0.08 mg/L
Vessel 2: 5.44 ± 0.01 mg/L
Vessel 3: 6.71 ± 0.12 mg/L
Mean: 5.84 ± 0.67 mg/L
Based on a copper content of 11 % the water solubility ofthe test item is:
Mean of concentration x 100 % / 11.0 %:
Vessel 1: 49.0 ± 0.7 mg/L
Vessel 2: 49.4 ± 0.1 mg/L
Vessel 3: 61.0 ± 1.1 mg/L
Mean: 53.1 ± 6.1 mg/L
Description of key information
Key value for chemical safety assessment
- Water solubility:
- 53.1 mg/L
- at the temperature of:
- 20 °C
Additional information
Under the conditions of the test (under exclusion of CO2 and O2, under inert gas; flask method; loadings of 430.8, 425.3 and 522.7 mg/L test substance in three replicate test vessels, a solubility equilibrium was not observed during testing. However, the dissolved copper concentration analysed on day 34 of testing is 5.84 ± 0.67 mg/L (determined as dissolved copper, separated by filtration from undissolved test item) at 20.0 ± 0.4 °C This corresponds to a water solubility of “fatty acids, C6-19-branched, copper salts” of 53.1 ± 6.1 mg/L, calculated on a copper content of 11.0 %.
The pH of solutions containing the test item ranged between 4.9 – 6.6. The pH in method blanks remained in the range of 6.1 – 7.8.
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