Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-354-5 | CAS number: 16230-35-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 27, 2017 - March 31, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature. - Key result
- Water solubility:
- ca. 35.864 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 1 - <= 3 d
- Temp.:
- 20 °C
- pH:
- >= 2.23 - <= 2.24
- Conclusions:
- The solubility of the test item at 20 ± 0.5 ºC and at pH ranging from 2.23 to 2.24 is 35.8642 g/L.
- Executive summary:
The study of the determination of test item solubility in water at one pH value using shake flask method was performed according to OECD 106 and EU method A.6, following GLP. The test item content in obtained samples for study of the solubility in the water values was determined by HPLC method, using a liquid chromatograph Shimadzu. The solubility of the test item at 20 ± 0.5 ºC and at pH ranging from 2.23 to 2.24 is 35.8642 g/L.
Reference
In the test, the following flasks were used:
Flasks 1 (samples 1 & 2) – for one day at 30ºC;
Flasks 2 (samples 3 & 4) – for two days at 30ºC;
Flask 3 (samples 5 & 6) – for three days at 30ºC.
The individual results from each of three flasks, which should not differ by more than 15%, are averaged. If the concentrations measured in at least the two last samples do not differ by more than 15% the test is satisfactory.
Water solubility is expressed in mass of solute per volume of solution.
Table 1. Results of the preliminary test
0.1g in x mL of solution |
0.1 |
0.5 |
1 |
2 |
10 |
Soluble (+/-) |
- |
- |
- |
- |
+ |
Approximate solubility, g/L |
> 1000 |
1000 to 200 |
200 to 100 |
100 to 50 |
50 to 10 |
x – water of pH 5.6
Table 2: Calibration solution
Day |
Weight [mg] |
Dilution [mL] |
Cw [mg/mL] |
Peak area |
Average peak area Aw |
f |
Average f |
|
1 |
29.35 |
25-0.9-25-3-10 |
0,01078 |
631743 |
631206 |
631474,5 |
0.0000171 |
0.00001731 |
25-0.9-25-5-10 |
0,01796 |
1031604 |
1013930 |
1022767 |
0.0000176 |
|||
2 |
25-0.9-25-2-10 |
0,00718 |
416655 |
420655 |
418655 |
0.0000172 |
0.00001717 |
|
25-0.9-25-4-10 |
0,01437 |
836136 |
837064 |
836600 |
0.0000172 |
|||
3 |
25-0.9-25-3-10 |
0,01078 |
631293 |
631206 |
418655 |
0.0000171 |
0.00001709 |
|
25-0.9-25-4-10 |
0,01437 |
842141 |
837181 |
836600 |
0.0000171 |
Table 3: Study solution in water
Sample day/ flask |
Weight of the sample [mg] |
Dilution [mL] |
Cp [mg/mL] |
Peak area |
Average peak area Ap |
X [g/kg] |
||
1 |
1 |
198.95 |
25-1-25 |
0.31832 |
638184 |
632191 |
635187.5 |
34.5503 |
2 |
197.80 |
0.31648 |
692855 |
696782 |
694818.5 |
38.0136 |
||
2 |
3 |
198.95 |
25-1-25 |
0.31832 |
673767 |
679972 |
676869.5 |
36.5080 |
4 |
198.55 |
0.31768 |
645816 |
647886 |
646851 |
34.9592 |
||
3 |
5 |
199.90 |
25-1-25 |
0.31984 |
676891 |
675701 |
676296 |
36.1370 |
6 |
198.65 |
0.31784 |
641299 |
661180 |
651239.5 |
35.0171 |
Table 4. Results ofN,N'-(ethoxymethylsilylene)bis[N-methylbenzamide]solubility
in water
Mixing timeat 30 ºC [days, flasks] |
1 |
2 |
3 |
|||
Samples |
1 |
2 |
3 |
4 |
5 |
6 |
Temperature, ºC |
20.0 |
20.1 |
20.1 |
|||
pH |
2.24 |
2.23 |
2.23 |
|||
Concentration ofN,N'-(ethoxymethylsilylene)bis[N-methylbenzamide], g/kg |
34.5503 |
38.0136 |
36.5080 |
34.9592 |
36.1370 |
35.0171 |
Averageconcentration ofN,N'-(ethoxymethylsilylene)bis[N-methylbenzamide],g/kg |
36.2820 ± 2.449 |
35.7336 ± 1.095 |
35.5771 ± 0.792 |
|||
Averageconcentrationof N,N'-(ethoxymethylsilylene)bis[N-methylbenzamide], g/kg |
35.8642 ± 0.370 |
The solubility of N,N'-(ethoxymethylsilylene)bis[N-methylbenzamide] in water is 36.1209 g/kg. The density of this solution is about 1kg/L (about water density). After recalculation:
The solubility of N,N'-(ethoxymethylsilylene)bis[N-methylbenzamide] in water
at 20 ± 0.5oC is 35.8642 g/L
Description of key information
Key study: OECD 105 and EU method A.6. GLP study. The solubility of the test item at 20± 0.5 ºC and at pH ranging from 2.23 to 2.24 is 35.8642 g/L.
Key value for chemical safety assessment
- Water solubility:
- 35.864 g/L
- at the temperature of:
- 20 °C
Additional information
Key study: The study of the determination of test item solubility in water at one pH value using shake flask method was performed according to OECD 106 and EU method A.6, following GLP. The test item content in obtained samples for study of the solubility in the water values was determined by HPLC method, using a liquid chromatograph Shimadzu. The solubility of the test item at 20± 0.5 ºC and at pH ranging from 2.23 to 2.24 is 35.8642 g/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)