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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-10-17 to 2018-02-01
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Deviations:
no
Type of method:
Laser scattering/diffraction
Type of particle tested:
agglomerate
Type of distribution:
volumetric distribution
Key result
Percentile:
D10
Mean:
1.58 µm
Remarks on result:
other: St. dev was not reported.
Key result
Percentile:
D50
Mean:
18.52 µm
Remarks on result:
other: St. dev was not reported.
Key result
Percentile:
D90
Mean:
427.9 µm
Remarks on result:
other: DMT-dT-Phosphoramidite is hygroscopic and has a strong tendency for agglomeration. The agglomeration had an influence on the test result. Also, St. dev was not reported.

The test item consists of transparent particles which appear partially needle-shaped and showed agglomeration. The agglomeration had influenced the test results.

The particle size distribution showed a polymodal distribution with three maxima and a shoulder. The first maximum was observed at approx. 6 µm, the second at approx. 80 µm and the third at approx. 400 µm. The shoulder was observed at approx. 0.5 µm.

Conclusions:
The particle size distribution of the test item was determined according to ISO13320:2009 by laser diffraction (light scattering):
D10: 1.58 µm;
D50: 18.52 µm;
D90: 427.9 µm.
The particle size distribution showed a polymodal distribution with three maxima and a shoulder. The first maximum was observed at approx. 6 µm, the second at approx. 80 µm and the third at approx. 400 µm. The shoulder was observed at approx. 0.5 µm.
Executive summary:

The particle size distribution of the test item was determined according to ISO13320:2009 by laser diffraction (light scattering):

D10: 1.58 µm;

D50: 18.52 µm;

D90: 427.9 µm.

The particle size distribution showed a polymodal distribution with three maxima and a shoulder. The first maximum was observed at approx. 6 µm, the second at approx. 80 µm and the third at approx. 400 µm. The shoulder was observed at approx. 0.5 µm. The test item has hygroscopic properties and therefore a strong tendency for agglomeration. Hence, it must be concluded that the D90 test result was influenced by the agglomeration.

Description of key information

The particle size distribution of the test item was determined according to ISO13320:2009 by laser diffraction (light scattering):

D10: 1.58 µm;

D50: 18.52 µm;

D90: 427.9 µm.

Additional information

The particle size distribution showed a polymodal distribution with three maxima and a shoulder. The first maximum was observed at approx. 6 µm, the second at approx. 80 µm and the third at approx. 400 µm. The shoulder was observed at approx. 0.5 µm. The test item has hygroscopic properties and therefore a strong tendency for agglomeration. Hence, it must be concluded that the D90 test result was influenced by the agglomeration.