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EC number: 218-451-9 | CAS number: 2155-60-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Based on the results obtained in a study performed in accordance with OECD 301F (Manometric Respirometry Test.), it can be concluded that Dibutyl itaconate is readily biodegradable. This conclusion is supported by BIOWIN calculations.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
The ready biodegradation of the substance was investigated according to OECD guideline 301 F and GLP principles. Test concentration of 37 mg/L was tested in six replicates for 28 days. The biodegradation values calculated from the O2 measurements performed during the test period of 28 days revealed significant biodegradation of the substance. At day 7, 42% biodegradation of the substance was observed, 68% at day 14 and 75% at day 28. Since biodegradation of at least 60% was reached within 10 days of biodegradation, the substance was concluded to be readily biodegradable. In the toxicity control, the substance was found not to inhibit microbial activity. The criteria for acceptability of the test were met and the study is considered to be reliable without restriction. In conclusion, the substance was determined to be readily biodegradable under the conditions of the Manometric Respirometry Test.
The two earlier performed Biodegradation studies (OECD 301B and 301D) are used as supporting evidence. The ready biodegradation of the substance under the conditions of the closed bottle test was investigated according to OECD 301D and GLP principles (reliable with restrictions, as not all specifications of the OECD TG 301 D were met). Test concentrations of 1 and 3 mg/L (2.2 and 6.54 mg ThOD/L) were tested in duplicate during 28 days. The relative biodegradation values calculated from the O2 measurements performed during the test period of 28 days revealed significant biodegradation of the substance. At day 7, 53% and 50% biodegradation of the substance at 1 and 3 mg/L, respectively, which was 63% and 60% at day 14. Since biodegradation of at least 60% was reached within 14 days of biodegradation exceeding 10%, the substance was concluded to be readily biodegradable.
Earlier the ready biodegradation of the substance was investigated according to OECD 301B (modified Sturm test) and GLP principles (reliable with restrictions, as not all validity criteria were met). In this study, the substance was also biodegraded significantly during the test period of 28 days. Only, as the pass level of 60% for ready biodegradability within the 10-day window was not met, it was not designated as readily biodegradable under the conditions of the modified Sturm test.
The substance is an ester that may hydrolyze in water to form butanol. Butanol is volatile and is expected to disappear in the modified Sturm test, while it does not disappear in the closed bottle test and the manometric respiratory test, in which all substances that arise are forced to stay into solution. Based on this and as there is no reason to question the test results obtained with the Manometric Respiratory test and supported by the results the closed bottle test, the substance is concluded to be readily biodegradable. This conclusion is supported by BIOWIN calculations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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