Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 252-917-2 | CAS number: 36211-43-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-04-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Version / remarks:
- 2015-07-28
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 2015-06-05
Test material
- Reference substance name:
- Barium 3,5,5-trimethylhexanoate
- EC Number:
- 252-917-2
- EC Name:
- Barium 3,5,5-trimethylhexanoate
- Cas Number:
- 36211-43-5
- Molecular formula:
- C9H18O2.1/2Ba
- IUPAC Name:
- barium 3,5,5-trimethylhexanoate
- Test material form:
- solid: particulate/powder
- Details on test material:
- - State of aggregation: solid; white powder
Constituent 1
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature, in a tightly closed container
In vitro test system
- Test system:
- artificial membrane barrier model
- Source species:
- other: not specified
- Cell type:
- other: synthetic macromolecular bio-barrier
- Cell source:
- other: not specified
- Source strain:
- not specified
- Details on animal used as source of test system:
- not applicable
- Justification for test system used:
- The CORROSITEX™ Assay is a standardized, quantitative in vitro test for skin corrosivity and has been validated by the ECVAM for testing acids, bases and their derivatives (ECVAM, 2000)*. The bio-barrier membrane is constructed to have physico-chemical properties similar to rat skin.
Reference:
- ECVAM (2000) ESAC statement on the application of the Corrositex® assay for skin corrosivity testing - Details on test system:
- WAS THE COMPATIBILITY TEST PERFORMED: yes
In order to test whether the test system is suitable for the test item, 100 mg of the test substance was added to the Qualify test tube. The vial was shaken and let stand for one minute. If the colour or consistency of the CDS changes at the sample/testing fluid interface, the test item is qualified for the assay. If no reaction is observed within five minutes, the sample is not qualified for the CORROSITEX TM assay.
The test substance was incompatible with the CORROSITEX™ Assay, as assessed in the qualification step. The categorization step and the classification step could not be performed.
TEST ACCEPTANCE CRITERIA:
The test meets acceptance criteria if:
- test item qualifies in qualification test
- positive control activates CDS > 3 - 60 min.
- negative control activates CDS not before 60 min.
The exact breakthrough time of the positive control should be determined to demonstrate, that the response is in the acceptable historical range of breakthrough times for the positive control (mean ± 2 - 3 standard deviations). - Control samples:
- not required
- Amount/concentration applied:
- not applicable
- Duration of treatment / exposure:
- not applicable
- Duration of post-treatment incubation (if applicable):
- not applicable
- Number of replicates:
- not applicable
Results and discussion
In vitro
Results
- Remarks on result:
- other: see "Remarks"
- Remarks:
- Barium bis(3,5,5-trimethyl hexanoate) was not able to activate the CDS within 5 min. in the qualification step. Therefore, the test substance was incompatible with the CORROSITEX™ Assay. The following categorization step and the classification step could not be performed. Hence, the in vitro skin corrosion potential of barium bis(3,5,5-trimethyl hexanoate) cannot be assessed in the membrane barrier test method.
- Other effects / acceptance of results:
- QUALIFICATION TEST
The test substance was incompatible with the CORROSITEX™ Assay, as assessed in the qualification step. The categorization step and the classification step could not be performed.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The test substance barium bis(3,5,5-trimethyl hexanoate) was not able to activate the CDS within 5 min. in the qualification step. Therefore the test substance was incompatible with the CORROSITEX™ Assay. The following categorization step and the classification step could not be performed.
Due to this technical limitation, the in vitro skin corrosion potential of barium bis(3,5,5-trimethyl hexanoate) cannot be assessed in the membrane barrier test method.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.