Registration Dossier
Registration Dossier
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EC number: 206-126-4 | CAS number: 302-72-7
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
- Remarks:
- Danish (Q)SAR Database, http://qsar.food.dtu.dk
- Justification for type of information:
- The literature reference of Yalkowsky 1992 is mentioned in the Danish QSAR database.
The database is developed by the National Food Institute, Technical University of Denmark, with support from the Danish Environmental Protection Agency, the Nordic Council of Ministers and the European Chemicals Agency. - Principles of method if other than guideline:
- not specified in the handbook
- Type of method:
- other: not specified in the handbook
- Water solubility:
- 166 000 mg/L
- Remarks on result:
- other: Temp not specified
- Conclusions:
- Water solubility Experimental: 166000 mg/L
DL-alanine is very water soluble
Reference
Description of key information
According to different values stated in two handbooks water solubility of D,L-alanin is in mean at 25 °C 157 g/L. The different stated values are all quite similar (please refer to 'Additional information'). The mean experimental value is supported by a theoretically derived water solubility.
Key value for chemical safety assessment
- Water solubility:
- 157 g/L
- at the temperature of:
- 25 °C
Additional information
CRC, Yalkowsky:
According to the CRC Handbook of aqueous solubility data, the water solubility of DL-Alanine is at 25 °C stated with different values (based on the specific source). In conclusion the arithmetic mean was chosen to state a definitive value:
(147.8 g/L + 142.2 g/L + 142.4 g/L + 143.2 g/L + 169.3 g/L + 136.3 g/L) / 5 = 146.9 g/L
CRC, Lange:
According to the CRC Lange's Handbook of chemistry , the water solubility of DL-Alanine is 167g/L at 25 °C.
Banerjee (1996), UNIFAC-estimated
The water solubility was calculated using an UNIFAC-based algorithm. A solubility of 1.5 - 3.8 M (133.7 - 338.6 g/L) was calculated for D,L-Alanine in the temperature range of 10 - 80 °C.
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