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Diss Factsheets
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EC number: 947-618-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Samples were taken at time 0h, 2h, 19h 24h, 90h and 120h (rounded values).
- Buffers:
- Buffer pH 4 Citric acid/NaOH/NaCl; Fluka, order no.: 33643
Buffer pH 7 KH2PO4/Na2HPO4, Fluka, order no.: 33646
Buffer pH 9 Na2B4O7/HCl, Fluka, order no.: 33648 - Details on test conditions:
- The substance was dissolved in buffer solution leading to a test item concentration of about 100 mg/L.
Aliquots of the stock solution were taken to obtain individual vials for every test point. To avoid the presence of oxygen the preparation was carried out under nitrogen as flushing gas,.
The vials were closed and incubated at 50 °C in a water bath under dark conditions to avoid any photolytic effects.
At each test point the hydrolysis solution was directly led to the chromatographic measurement.
The pH of the blank buffer solution was checked at the beginning of the test. Additionally the pH of the hydrolysis solution was measured at each test point.
The suitability of the HPLC system during the hydrolysis study was verified on every day of application. The calibration was verified daily at the level of 108 mg/L by using a control calibration solution. - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 100 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 100 mg/L
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 100 mg/L
- Preliminary study:
- The overall degradation of the test item at 50 °C at pH 4, 7 and 9 after 5 days is less than 10 %. Therefore no main test was performed.
- Transformation products:
- no
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 5 d
- Type:
- not specified
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 5 d
- Type:
- not specified
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 5 d
- Type:
- not specified
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- The overall degradation of the test item at 50 °C at pH 4, 7 and 9 after 5 days is less than 10 %. The test item is therefore considered to be stable at 50 °C at pH 4 and no half-life time and hydrolysis rate were calculated. Because no degradation was observed, no sterility test was performed in this case. No further tests at other temperatures are required
- Validity criteria fulfilled:
- yes
- Conclusions:
- The substance is hydrolytically stable at 50 °C at pH 4, 7 and 9.
- Executive summary:
In a test according to OECD 111, the overall degradation of the test item at 50 °C at pH 4, 7 andafter 5 days is less than 10 %. The substance is therefore considered to be stable at 50 °C at pH 7 and no half-life time and hydrolysis rate were calculated. Because no degradation was observed, no sterility test was performed in this case. No further tests at other temperatures are required.
Reference
Description of key information
The overall degradation of the test item at 50 °C at pH 4, 7 and 9 after 5 days is less than 10 %. The substance is therefore considered to be stable at 50 °C at pH 7 and no half-life time and hydrolysis rate were calculated.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.