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EC number: 238-677-1 | CAS number: 14634-93-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: REACH regulation EC/1907/2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guidelines for Testing of Chemicals, Section 1 – Physical-Chemical Properties No: 105
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Council Regulations EC No 440/2008, Guideline Part A – Methods for the Determination of Physico-Chemical Properties, A.6.
- Principles of method if other than guideline:
- To determine the octanol solubility of the test item, the shake flask method according to OECD Guideline 105 and EC Guideline A.6 can be used.
In a preliminary test, the octanol solubility of the test item was found to be approximately 186 mg/L.
For the main test, a quantity of the test item necessary for saturation is dissolved in octanol. The vessels are stoppered and stirred on a magnetic stirrer for 24 h, 48 h and 72 h at 30 °C in a temperature controlled water bath. Following this procedure, the temperature is reduced to 20 °C and is kept in the temperature controlled water bath for another 24 h. After phase separation by filtration with a disposable syringe filter and/or centrifugation, the concentration of the test item in the aqueous test solutions is determined.
Remark: Since the test item is not soluble in the most organic solvents in sufficient quantity the concentration of the test item in octanol were determined by Zn analysed via ICP-MS. - GLP compliance:
- yes
- Specific details on test material used for the study:
- Batch number: CN61204501
Date of receipt: 2017-03-02
Expiry date: 2017-12-04 (the test item was not used after expiry date) - Medium:
- n-octanol
- Solubility:
- 160 mg/L
- Temp.:
- 20 °C
- Remarks on result:
- other: Flask A
- Medium:
- n-octanol
- Solubility:
- 196 mg/L
- Temp.:
- 20 °C
- Remarks on result:
- other: Flask B
- Medium:
- n-octanol
- Solubility:
- 168 mg/L
- Temp.:
- 20 °C
- Remarks on result:
- other: Flask C
- Test substance stable:
- yes
- Details on results:
- The results are based on different Zn contents.
In a preliminary test the concentration found was approx. 180 mg/L. Therefore the concentration for the main test was set to 900 mg/L. This corresponds to 5 times the concentration found in the pretest. - Conclusions:
- By means of different calculation approaches the octanol solubility of Vulkacit P Extra N was found to vary between 160 and 196 mg/L at 20°C according to OECD guideline 105.
- Executive summary:
The octanol solubility of the test item Vulkacit P Extra N was determined based on the shake flask method at 20 °C according to OECD guideline 105.
The test item concentration in the octanol test solutions was obtained by determination of the zinc (Zn) content via ICP-MS analysis.
By means of different calculation approaches the octanol solubility of the test item was found to vary between 160 and 196 mg/L:
Content of Zn used for evaluation [%] 17.51 14.32 16.73 Determined concentration of the test item in the octanol solutions [mg/L] 160 196 168 1 Overall Zn content
2 Theoretical Zn content
3 Overall Zn content corrected by determined purity (95.5 %)
In a preliminary test, the octanol solubility of the test item was found to be approximately 186 mg/L.
Since the test item is not soluble in the most organic solvents in sufficient quantity the concentration of the test item in octanol were determined by Zn analysed via ICP-MS.
Reference
Results of single determinations and mean value
Octanol solubility test at 20 °C | Concentration of Zn in octanol solution 1/2 | Concentration of Zn in octanol solution 2/2 | Mean value |
Flask A [mg/kg] | 36 | 36 | 36 |
Flask B [mg/kg] | 28 | 35 | 32 |
Flask C [mg/kg] | 35 | 35 | 35 |
Overall mean | - | - | 34 |
The relative standard deviation between the single determinations is < 15 %. The validity criteria have therefore been met.
The determined concentrations in mg/kg were used to determine the octanol solubility in mg/L using a density of octanol of 0.817 kg/L.
The content of Zn in the test item was 17.5 %.
The test item has a theoretical concentration of Zn of 14.3 %.
Additionally ZnO could be determined and the content was calculated to be 4 %. The purity of the test item was 95.5 %. Therefore the corrected Zn content is 16.7 %.
Description of key information
The octanol solubility of the test item Vulkacit P Extra N was determined based on the shake flask method at 20 °C according to OECD guideline 105.
The test item concentration in the octanol test solutions was obtained by determination of the zinc (Zn) content via ICP-MS analysis.
By means of different calculation approaches the octanol solubility of the test item was found to vary between 160 and 196 mg/L:
Content of Zn used for evaluation [%] | 17.51 | 14.32 | 16.73 |
Determined concentration of the test item in the octanol solutions [mg/L] | 160 | 196 | 168 |
1 Overall Zn content
2 Theoretical Zn content
3 Overall Zn content corrected by determined purity (95.5 %)
In a preliminary test, the octanol solubility of the test item was found to be approximately 186 mg/L.
Since the test item is not soluble in the most organic solvents in sufficient quantity the concentration of the test item in octanol were determined by Zn analysed via ICP-MS.
Key value for chemical safety assessment
- At the temperature of:
- 20 °C
- Solubility in organic solvents at 20°C:
- 160 mg/L
Additional information
Octanol solubility varies between 160 and 196 mg/L.
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