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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 239-044-2 | CAS number: 14970-87-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Principles of method if other than guideline:
- The PubChem BioAssay database was searched for chemogenomic, medicinal chemistry and functional genomics biological activities
- Type of method:
- in vivo
- Specific details on test material used for the study:
- PubChem CID: 84733
Substance SID: 144211799 - Details on results:
- 150 bioassays were retrieved from the PubChem BioAssay data base. DMDO was inactive in 136 bioassays and inconclusive in 14 bioassays.
- Executive summary:
The PubChem BioAssay database was searched for chemogenomic, medicinal chemistry and functional genomics biological activities. 150 bioassays were retrieved. DMDO was inactive in 136 bioassays and inconclusive in 14 bioassays. DMDO had no agonist and antagonist activities on the androgen receptor (AR), estrogen receptor alpha (ER-alpha), peroxisome proliferator-activated receptor gamma (PPARg) and delta (PPARd), glucocorticoid receptor (GR) and the farnesoid-X-receptor (FXR) signaling pathways.
Reference
The list of all the assays performed is displayed in the enclosed excel file.
Description of key information
Using a high-throughput robotic screening system (US EPA, 2017), DMDO was assessed for its potential to disrupt biological pathways (nuclear factor, erythroid 2-like 2, androgen receptor, aryl hydrocarbon receptor, cytochrome P450, family 19, subfamily A, polypeptide 1, ATPase family, AAA domain containing 5, estrogen receptor 1, activating transcription factor 6, nuclear receptor subfamily 1, group H, member 4, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), heat shock transcription factor 1, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, peroxisome proliferator-activated receptor delta, thyroid hormone receptor, beta, cytochrome P450, family 24, subfamily A, polypeptide 1, and tumor protein p53) that may result in toxicity. 113 assays were performed. Cytotoxicity was assessed in 20 assays, no cytotoxicity was observed up to 100µM. DMDO induced a positive response in only 2 assays, which were flagged as "Noisy data" and deemed not reliable. Therefore, there is no evidence that DMDO could interfere with the expression of the screened genes.
The PubChem BioAssay database was searched for chemogenomic, medicinal chemistry and functional genomics biological activities (NCBI, 2017). 150 bioassays were retrieved. DMDO was inactive in 136 bioassays and inconclusive in 16 bioassays. DMDO had no agonist and antagonist activities on the androgen receptor (AR), estrogen receptor alpha (ER-alpha), peroxisome proliferator-activated receptor gamma (PPARg) and delta (PPARd), glucocorticoid receptor (GR) and the farnesoid-X-receptor (FXR) signaling pathways.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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