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EC number: 288-509-6 | CAS number: 85736-97-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10-07-1989 - 14-07-1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Nominal test concentration above water solubility.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- Test was performed above water solubility of the test substance
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Specification: Zebra fish (Brachydanio rerio) HAMILTON-BUCHANAN, Teleostei, Cyprinidae.
Source: German bred; Distributor: Doller, Zierfischzüchterei,Finnentrop-Serkenrode.
Size: 3.0 ± 0.5 cm.
Holding: The test organisms were acclimatised for at least 12 days before start of the test in dilution water of the
same quality as used for the test. The fish were fed daily with TetraMin® Hauptfutter until 24 h before the test.
Mortality: The criteria of the guideline OECD 203 were applied. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 23 °C ± 1 °C
- pH:
- 7.8 ± 0.2
- Dissolved oxygen:
- 7.88 mg/l
- Nominal and measured concentrations:
- 0 (blank), 1.0, 10,
100, 1000 , 10000 mg/l. - Details on test conditions:
- Dilution water was prepared according to the test guideline (OECD 203) following internal SOP’s.
Test concentrations:
Aliquots of the stock solution were mixed with dilution water. The volume of the test solution was adjusted to 10 l each.
Test priciples and procedure:
10 fish were used for each test concentration including controls.
Only fish in good health and free from any apparent malformation were used.
Numbered 10-l glass aquaria were used as test vessels and Filled with 5 l of test-solution. The test animals were added to the previously prepared test solution; controls were kept in dilution water (blank).
The aquaria were slightly aerated via a glass capillary throughout the test.
The fish were exposed to various concentrations of the test substance for a period of 96 hours under static conditions. Visible abnormalities
observed during the first 6 hours of the experiment were recorded. Mortalities and visual abnormalities were recorded at 24 h, 48 h, 72 h, and 96 h.
The test temperature was 23° C ± l °C. The pH of the dilution water was 7.8 ± 0.2.
The light/dark rhythm was 14h/l0h.
The pH and the oxygen concentrations of the control and of all the test concentrations were measured daily. - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Sublethal observations / clinical signs:
Concentration-effect relationship Isotridecyl methacrylate
48 h
96 h
LC0(mg/l)
LC50(mg/l)
LC100(mg/l)
95% confidence limits
(LC50, mg/l)
slope
chi-square
> 10000
> 10000
> 10000
---
---
---
> 10000
> 10000
> 10000
---
---
---
- Validity criteria fulfilled:
- yes
- Remarks:
- with restrictions (water solubility)
- Conclusions:
- According to the presented results, the test substance isotridecyl methacrylate is classified as non-toxic to fish (Danio rerio).
- Executive summary:
In a 96 h fish acute toxicity test (OECD 203, GLP) Zebra fish (Danio rerio) were exposed to isotridecyl methacrylate at nominal concentrations of 1.0, 10, 100, 1000 and 10000 mg/l. No mortalities were observed, the LC0 value was > 10000 mg/l.
COMMENT: Concentrations used in the test are clearly above the water solubility of isotridecyl methacrylate. Despite the fact that the test therefore has to be considered as limited in validity from a technical point of view, it can be concluded that saturated solutions of the substance are non-toxic to fish.
NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.
Reference
Description of key information
An OECD 203 guideline GLP study with nominal test concentrations above 10000 mg/L showed no toxicity to Danio rerio.
Therefore, it appears that saturated solutions of Isotridecyl methacrylate are non-toxic to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 10 000 mg/L
Additional information
LC50 [96 h] > 10000 mg / L
Concentrations used in the available test are five orders of magnitude above the water solubility of Isotridecyl methacrylate, which is < 1 µg/L. Therefore, emulsions or even two-layer systems of the test item with water have been tested instead of solutions setting a limitation to the validity of the study. However, it appears that saturated solutions of the substance are non-toxic to fish.
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