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Diss Factsheets
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EC number: 201-782-8 | CAS number: 87-90-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed to GLP, no guideline specified.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
- Principles of method if other than guideline:
- The 59 day study was designed to evaluate the toxicity of s-triazinetriol monosodium salt (cyanuric acid, monosodium salt) to rats and to establish dosage levels to be used in a 13 week toxicity study.
- GLP compliance:
- yes
Test material
- Reference substance name:
- s-triazinetriol monosodium salt (cyanuric acid, monosodium salt)
- IUPAC Name:
- s-triazinetriol monosodium salt (cyanuric acid, monosodium salt)
- Details on test material:
- - Name of test material (as cited in study report): s-triazinetriol monosodium salt (cyanuric acid, monosodium salt) equivalent to 77.34% CYA.
- Substance type: fine white powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River CD® rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Inc., Portage, Michigan, USA
- Age at study initiation: ~ 3 weeks
- Weight at study initiation: Males: 84 – 100 g, Females: 84 – 101 g
- Housing: wire-mesh cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 9 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 68-70
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Details on oral exposure:
- PREPARATION OF DOSING SOLUTIONS: A suitable amount of the test compound was dissolved in tap water, on a stir plate to yield test solutions. The pH of the test solutions was adjusted to 7.2-7.6 (using sodium hydroxide and glacial acetic acid) and the solutions aged for 4 days in vented containers at room temperature. Before the test solutions were offered to the animals, the pH was readjusted to 7.2 - 7.6, if necessary. Fresh test solutions were prepared twice a week, 4 days prior to administration.
- Duration of treatment / exposure:
- 28 days extended to 59 days
- Frequency of treatment:
- Continuous
Doses / concentrations
- Remarks:
- Doses / Concentrations:
400, 1200, 2000 and 4000 ppm equivalent to CYA concentrations of 48.8, 141.4, 260.1, 520.7 mg/kg (males) and 64.5, 264.2, 370.4, 717.0 mg/kg bw/d (females) bw/d;
Basis:
nominal in water
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent no treatment
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: Twice daily/7 days a week
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: Weekly
BODY WEIGHT: Yes
- Time schedule for examinations: Twice weekly
FOOD CONSUMPTION: Yes
- Time schedule for examinations: Weekly
WATER CONSUMPTION AND COMPOUND INTAKE (if drinking water study): Yes
- Time schedule for examinations: Three times a week
OPHTHALMOSCOPIC EXAMINATION: No
HAEMATOLOGY: Yes
- Time schedule for collection of blood: end of study (week 9)
- How many animals: all animals
- Parameters checked: haematocrit, haemoglobin concentration, erythrocyte count, total and differential leukocyte count, platelet count, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration and reticulocyte count.
CLINICAL CHEMISTRY: Yes
- Time schedule for collection of blood: end of study (week 9)
- How many animals: all animals
- Parameters checked: glucose, cholesterol, blood urea nitrogen, total bilirubin, creatinine, total protein, albumin, alkaline phosphatase, serum glutamic oxaloacetate transamine, serum glutamic pyruvic transaminase, calcium, lactic dehydrogenase, phosphorous, sodium, potassium, chloride, globulin, (calculated) and osmolarity
URINALYSIS: Yes
- Time schedule for collection of urine: end of study (week 9)
- Metabolism cages used for collection of urine: Yes
- Parameters checked: colour and appearance, volume, osmolality, specific gravity, pH, protein, glucose, occult blood ketones, bilirubin, nitrite, urobilinogen, microscopic examination of sediment, sodium, potassium, chloride, phosphorous, calcium, creatinine, urea nitrogen
- Sacrifice and pathology:
- GROSS PATHOLOGY: : All gross lesions, adrenals, eye, trachea, duodenum, jejunum, ileum, cecum, colon, ureters, brain, spinal cord, pituitary, thyroid, parathyroid, thymus, oesophagus, submaxilliary salivary glands, stomach, small and large intestines, liver, pancreas, kidneys, spleen, heart, lungs with bronchi, aorta, gonads, uterus, prostate, urinary bladder, gall bladder (mouse), mesenteric lymph node, peripheral nerve, bone marrow, skin, mesenteric lymph node, sternum, skeletal thigh muscle, peripheral nerve
HISTOPATHOLOGY: Microscopic examination of hematoxylin and eosin stained sections of ureters, urinary bladders and Buoin’s fluid fixed kidneys for all animals in the control group, s-triazinetriol monosodium salt treated groups. Histopathology was not performed on terminal sacrifice animals treated with the chlorinated compounds. - Statistics:
- All statistical analyses compared the treatment groups of each compound with the control group, by sex.
Body weights (weeks 4 and 8), water consumption (weeks 4 and 8), haematological, biochemical and urinalysis parameters (day 59) and absolute and relative organ weights (terminal sacrifice) were compared by ANOVA. Dunnett’s multiple comparison tables were used to judge significance of difference.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Water consumption and compound intake (if drinking water study):
- no effects observed
- Ophthalmological findings:
- not examined
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
Effect levels
open allclose all
- Dose descriptor:
- LOAEL
- Effect level:
- > 4 000 ppm
- Sex:
- male/female
- Basis for effect level:
- other: (males >521 mg/kg bw/d; females >717 mg/kg bw/d)
- Dose descriptor:
- NOAEL
- Effect level:
- 4 000 ppm
- Sex:
- male/female
- Basis for effect level:
- other: (males 521 mg/kg bw/d; females 717 mg/kg bw/d)
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Haematology:
All values were within the normal range. Occasional values were statistically significant, although the absolute differences were small. Albumin, globulin and serum protein values were slightly elevated in high dose males which may be suggestive of hemoconcentration, although water consumption and urine volume were normal.
Clinical chemistry:
All values were within the normal range. Occasional values were statistically significant, although the absolute differences were small. Glucose values for males and females at the 4000 ppm dosage level were significantly greater than the control values, although the difference between the high dose and control values was not. All values were within the normal range for this laboratory
Urinlaysis:
Urine values were within the normal range, except for urea nitrogen which was significantly decreased in female rats at 1200 ppm and in both male and female rats at 4000 and 8000 ppm, by around 50%.
Organ weights:
No statistically significant organ weight variations of livers and kidneys were noted
Gross and histopathology:
No gross or microscopic lesions of treatment-related significance were noted
Applicant's summary and conclusion
- Conclusions:
- LOAEL (CYA) >521 mg/kg bw/d (males); >717 mg/kg bw/d (females)
NOAEL (CYA) 521 mg/kg bw/d (males); 717 mg/kg bw/d (females)
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