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EC number: 231-640-0 | CAS number: 7665-72-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978-10-27 to 1979-06-08
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- no
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: lot number 04078 (XAS-1467)
- Purity: 99.20 %
- Sample composition: t-BGE (99.20 %), t-butoxy-2-propanol (0.34 %), tri-isobutylene (0.14 %), t-butanol (0.10 %), unidentified (0.22 %)
- Physical state: clear liquid, stable during test conditions
- Solubility in water: 40 g/L at 25 °C - Analytical monitoring:
- not specified
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: method of preparation not reported - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna Straus, water flea
- The daphnids used for testing were raised in the 1702 Building Fish Laboratory. - Test type:
- static
- Water media type:
- other: declorinated Lake Huron water
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 20 °C
- Nominal and measured concentrations:
- [mg/L]: 1.00, 1.80, 5.60, 10.00, 18.00 (see also Table 1 in Any other information on materials and methods incl. tables.)
- Details on test conditions:
- EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Mortality, %Response; daily
In the daphnid toxicity test, water flea (Daphnia magna STRAUS) were exposed for 48 h at 20 °C. An initial range finding test was used to determine the concentration series to be used in the definitive test. Definitive tests were rerun until the mortality data met the conditions for statistical analysis; for the daphnids toxicity test there were four runs - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- other: No Adverse Effect Level
- Effect conc.:
- < 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95%-C.I.: 10-31 mg/L
- Duration:
- 48 h
- Dose descriptor:
- other: Partial Kill Level
- Effect conc.:
- 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95%-C.I.: 10-31 mg/L
- Duration:
- 48 h
- Dose descriptor:
- other: 100 % Kill Level
- Effect conc.:
- > 7.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95%-C.I.: 10-31 mg/L
- Duration:
- 48 h
- Dose descriptor:
- LC10
- Effect conc.:
- 2.36 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95%-C.I.: 0.67-3.92 mg/L
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 14.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95%-C.I.: 10.3-31.3 mg/L
- Duration:
- 48 h
- Dose descriptor:
- other: LC90
- Effect conc.:
- 94.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95%-C.I.: 40.3-981.5 mg/L
- Details on results:
- - Behavioural abnormalities: no abnormalities were mentioned
- Observations on body length and weight: no abnormalities were mentioned
- Mortality of control:
- Other adverse effects control:
- Abnormal responses:
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values:
- Effect concentrations exceeding solubility of substance in test medium: - Reported statistics and error estimates:
- LC values were calculated from the observed mortality data using a computer program of Finney's method of probit analysis.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 48-hr-Static acute Daphnid Toxicity test of the test material showed moderate toxicity to daphnids. The 48-hr LC50 for daphnids (Daphnia magna Straus) was 14.92 mg/L (95%-C.I.: 10-31 mg/L).
- Executive summary:
The 48–hr-acute toxicity of tert-butyl glycidyl ether to Daphnia magna Straus was studied under static conditions. Daphnids were exposed to tert-butyl glycidyl ether at nominal concentration of 1.00, 1.80, 5.60 10.00 and 18.00 mg/L for 48 hr.
Mortalilty was observed daily.
The 48 – hr LC50 was 14.92 mg/L.
Based on the results of this study, tert-butyl glycidyl ether would not be classified as toxic to Daphnia magna Straus in accordance with the CLP classification system.
This study is classified as acceptable and satisfies the guideline requirements for an acute toxicity study with freshwater invertebrates.
Results Synopsis
Test Organism Age (e.g. 1st instar):
Test Type: Static
- 48 hr LC10: 2.36 mg/L 95% C.I.: 10-31 mg/L
- 48 hr LC 50: 14.92 mg/L 95% C.I.: 10 -31 mg/L
- 48 hr LC 90: 94.25 mg/L 95% C.I.: 10 -31 mg/L
- 48 hr NOAEL: < 1.0 mg/L
- 48 hr Partial Kill Level: 1.0 mg/L
- 48 hr 100 % Kill Level: > 7.2 mg/L
Endpoints effected: Mortality
Reference
Description of key information
In a 48-hr-static acute Daphnid Toxicity, t-BGE showed moderate toxicity to daphnids. The 48-hr LC50 for daphnids (Daphnia magna Straus) was 14.92 mg/L (95%-C.I.: 10-31 mg/L).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 14.92 mg/L
Additional information
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