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EC number: 215-851-5 | CAS number: 1429-50-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 32 days
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
- Objective of study:
- other:
- Principles of method if other than guideline:
- This study investigated the effects of treatment with EDITEMPA following 10 days of treatment with compound in the feed. 15 mg and 150 mg/kg (bw) were used to enable direct comparison with the other studies. However, based on food consumption data the actual doses were determined to be 19 mg/kg (bw) and 196 mg/kg (bw) respectively. 20 Male rats were used at each dose level.
- GLP compliance:
- yes
Test material
- Reference substance name:
- [ethylenebis[nitrilobis(methylene)]]tetrakisphosphonic acid, sodium salt
- EC Number:
- 244-742-5
- EC Name:
- [ethylenebis[nitrilobis(methylene)]]tetrakisphosphonic acid, sodium salt
- Cas Number:
- 22036-77-7
- Molecular formula:
- C6H20N2O12P4.xNa
- Test material form:
- not specified
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- other: Rat (Sprague Dawley)
- Strain:
- other: Sprague Dawley rats
- Sex:
- male
Administration / exposure
- Route of administration:
- other: Dietary and by oral gavage
- Vehicle:
- unchanged (no vehicle)
- Duration and frequency of treatment / exposure:
- This study investigated the effects of treatment with EDITEMPA following 10 days of treatment with compound in the feed. 15 mg and 150 mg/kg (bw) were used to enable direct comparison with the other studies. However based on food consumption data the actual doses were determined to be 19 mg/kg (bw) and 196 mg/kg (bw) respectively. 20 Male rats were used at each dose level.
Doses / concentrationsopen allclose all
- Dose / conc.:
- 15 mg/kg bw/day
- Remarks:
- EDITEMPA was dissolved in NaOH with pH adjustement to achieve pH 7.
- Dose / conc.:
- 150 mg/kg bw/day
- No. of animals per sex per dose / concentration:
- Males
- Control animals:
- no
Results and discussion
- Preliminary studies:
- Little/insignificant amounts of radioactivity were detected in blood. Urinary elimination of 14C was limited, less than 1% of the last dose was recovered in urine from either group. Most radioactivity was recovered in faeces, primarily during the first 24 hours following termination of treatment. No differences in excretion patterns seen in the groups. Levels of 14C was low, no changes in tissue distribution of 14C were noted between the two groups. Recovery in bone was relatively high, ranging from 0.6 -1.1% (low dose) and 0.3-0.7% (high dose). After low dose the areas under the bone concentration time curve (AUC) were 52 and 45 micrograms/gram/day in femur and tibia respectively. After the high dose levels these were 333 and 259 micrograms/gram/day, respectively. The levels in vertebrae were slightly lower. Disappearance of 14C from vertebrae was slower (t ½ 40-43 days) than femur (20-38 days) and tibia (30-32 days).
This study demonstrates that following 10 day treatment with EDITEMPA mixed in feed accumulation and retention is limited to the bone.
Compared to multiple oral gavage dosing, less absorption of the test compound was apparent, shown by lower blood and tissue levels. Treatment at low doses in feed or by gavage resulted in similar levels of 14C in the bone. However, after high doses bone levels decreased three fold in animals fed with 14C EDITEMPA diets.
Applicant's summary and conclusion
- Conclusions:
- This study demonstrates that following 10 day treatment with EDITEMPA mixed in feed accumulation and retention is limited to the bone. Compared to multiple oral gavage dosing, less absorption of the test compound was apparent, shown by lower blood and tissue levels. Treatment at low doses in feed or by gavage resulted in similar levels of 14C in the bone. However, after high doses bone levels decreased three fold in animals fed with 14C EDITEMPA diets.
- Executive summary:
This study investigated the effects of treatment with EDITEMPA following 10 days of treatment with compound in the feed. Doses of 15 mg and 150 mg/kg (bw) were used to enable direct comparison with the other studies. However based on food consumption data the actual doses were determined to be 19 mg/kg (bw) and 196 mg/kg (bw) respectively. 20 Male rats were used at each dose level. The results of this study demonstrates that following 10 day treatment with EDITEMPA mixed in feed accumulation and retention is limited to the bone. Compared to multiple oral gavage dosing, less absorption of the test compound was apparent, shown by lower blood and tissue levels. Treatment at low doses in feed or by gavage resulted in similar levels of 14C in the bone. However after high doses bone levels decreased three fold in animals fed with 14C EDITEMPA diets.
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