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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From November 30, 2017 to January 09, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- CAS No.: 162492-01-5 (or 264888-31-5); EINECS-No.: 500-734-6; Batch No.: DR0072912; Appearance: transparent viscous liquid, Purity: 100 % (UVCB); Homogeneity: homogeneous
- Key result
- Water solubility:
- 0.1 vol%
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 1 000 mg/L
- Incubation duration:
- 7 d
- Temp.:
- 20 °C
- pH:
- 6
- Details on results:
- Test I: (nominal loads 1 – 10 g/L and 103 – 1004 mg/L). The measured values of the main test 1 showed great variation. The solubility range for nominal test substance concentration is established at 1 – 10 g/L (1.12 – 7.17 mg/L), corresponding to 0.1 % of the test substance.
Test II: (nominal loads 306 – 1004 mg/L) The solubility range for nominal test substance concentration is established at 0.38 – 0.85 mg/L.
The same fraction of dissolved part (0.1 %) relating to the nominal concentration of the test substance was calculated in both tests. - Conclusions:
- Under the study conditions, the solubility range for the tested nominal concentration 306 – 1004 mg/L is 0.38 – 0.85 mg/L, corresponding to 0.1 % of the test item relating to the nominal concentration of the test item (mean value).
- Executive summary:
A study was conducted to determine the solubility of the test substance according to OECD Guideline 105 and EU Method A.6, in compliance with GLP. The solubility of the test substance was measured as DOC concentration in the filtrated test solutions using TOC analyser. The slow-stirring flask method was chosen for the determination of the solubility of the test substance in water. Vario TOC cube analyser with better sensitivity was used in the main test. The main test was performed two times (nominal loads 1 – 10 g/L and 103 – 1004 mg/L) as the measured values of the main test 1 showed great variation. As solubility was dependent on nominal concentration, no exact value for the solubility of the test substance in water can be stated. The solubility range for the tested nominal concentration 1 – 10 g/L is 1.12 – 7.17 mg/L, corresponding to 0.1 % of the test substance relating to the nominal concentration of the test substance (mean value). In the main test 2, solubility range for the tested nominal concentration 306 – 1004 mg/L was 0.38 – 0.85 mg/L. The same fraction of dissolved part (0.1 %) relating to the nominal concentration of the test isubstance was calculated in both tests. Under the study conditions, the solubility of the test substance the solubility range of the test substance in water for the tested nominal concentration 306 – 1004 mg/L is 0.38 – 0.85 mg/L, corresponding to 0.1 % of the test substance relating to the nominal concentration (mean value) (Affolter, 2018).
Reference
Description of key information
The water solubility was determined according to OECD Guideline 105 and EU Method A.6 (Affolter, 2018).
Key value for chemical safety assessment
- Water solubility:
- 0.85 mg/L
- at the temperature of:
- 20 °C
Additional information
As solubility was dependent on nominal concentration, no exact value for the solubility of the test substance in water can be stated. The solubility range for the tested nominal concentration 306 – 1004 mg/L is 0.38 – 0.85 mg/L, corresponding to 0.1 % of the test substance relating to the nominal concentration (mean value).
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