Registration Dossier
Registration Dossier
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EC number: 642-981-3 | CAS number: 148465-73-0
Endpoint summary
Administrative data
Description of key information
Mucorpepsin has been tested in the daphnia immobilisation test. Read-across to subtilisin is applied for the acute toxicity towards fish and read across to beta-N-acetylhexosaminidase for the algal growth inhibition study.
Daphnia immobilisation test: The 48h EC50 value for Mucorpepsin batch PPR 3583 was determined to 398 mg enzyme concentrate dry matter/L, equivalent to 117 mg active enzyme protein/L and the no-observed-effect concentration 42.5 mg enzyme concentrate dry matter/L, equivalent to 12.5 mg active enzyme protein/L.
Read-across from beta-N-acetylhexosaminidase (another hydrolase) gave similar results.
Algal growth inhibition (read across from beta-N-acetylhexosaminidase: ErC50 > 260.7 mg enzyme concentrate dry matter/L (equivalent to 100 mg active enzyme protein/L). NOEC for both growth rate and yield was 65.2 mg enzyme concentrate dry matter/L and LOEC was 130.4 mg enzyme concentrate dry matter/L. Yield EbC50 was 101.7 mg enzyme concentrate dry matter/L.
Fish acute toxicity (read-across from subtilisin): The measured 96-hour LC50 was 15.6 mg enzyme concentrate dry matter/L (measured as 8.2 mg active enzyme protein/L). Measured 100% mortality was 52.6 mg enzyme concentrate dry matter/L (measured as 27.6 mg active enzyme protein/L).
The NOEC was not clearly identified during the definitive test but based on the findings of a range finding test, it was 10.7 mg enzyme concentrate dry matter/L (nominal) (5.6 mg active enzyme protein/L).
The LC50 value from the fish acute toxicity study is used for PNEC derivation.
Additional information
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