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Diss Factsheets
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EC number: 211-541-9 | CAS number: 660-68-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2003
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientific publication that meets documentation requirements.
- Justification for type of information:
- refer to analogue justification provided in IUCLID section 13
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
- Objective of study:
- other: ADME
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diethylamine
- EC Number:
- 203-716-3
- EC Name:
- Diethylamine
- Cas Number:
- 109-89-7
- Molecular formula:
- C4H11N
- IUPAC Name:
- N-ethylethanamine
Constituent 1
- Radiolabelling:
- no
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Excerpt from NTP Report about ADME of diethylamin:
Very little information on the disposition and metabolism of diethylamine in experimental animals or humans was found in a review of the literature. The reaction of dietary amines with nitrite to produce nitrosamines, which are potential carcinogens, has been demonstrated both in vitro and in vivo (Sander, 1967; Sander et al., 1968; Mirvish, 1975). However, in Wistar rats administered 600 ppm diethylamine and sodium nitrite in the diet, diethylnitrosamine could not be detected (Galea et al., 1975). Diethylnitrosamine was not detected in blood or milk of goats fed kale containing 3% potassium nitrate followed by administration of a single oral dose of 200 mg/kg diethylamine hydrochloride (Juskiewicz and Kowalski, 1976). Monoamine oxidase is assumed to play an important role in the metabolism and detoxification of the aliphatic amines. Monoamine oxidase catalyzes the deamination of primary, secondary, and tertiary amines. Monoamine oxidase is widely distributed in tissues and is most concentrated in the liver, kidney, and intestinal mucosa (Beard and Noe, 1981). Traces of diethylamine (less than 0.5% of the dose) were detected in the urine of human volunteers following oral doses of triethylamine (Åkesson et al., 1989). Diethylamine was also found in the gastro-intestinal tract after oral doses of triethylamine-N-oxide, the oxidative metabolite of triethylamine, indicating that triethylamine-N-oxide is dealkylated in the gastro-intestinal tract to diethylamine. There was no evidence that diethylamine produced from triethylamine-N-oxide was subsequently metabolized to N-nitrosodiethylamine in the stomach.
References:
Åkesson, B., Vinge, E., and Skerfving, S. (1989). Pharmacokinetics of triethylamine and triethylamine-N-oxide in man. Toxicol. Appl. Pharmacol. 100, 529-538.
Beard, R.R., and Noe, J.T. (1981). Aliphatic and alicyclic amines. In Patty’s Industrial Hygiene and Toxicology, 3rd ed. (D.G. Clayton and F.E. Clayton, Eds.), Vol. 2B, pp. 3135-3173. Wiley-Interscience Publication, New York, NY.
Galea, V., Preda, N., and Simu, G. (1975). Experimental production of nitrosamines in vivo. IARC Sci. Publ. (N-Nitroso Compd. Environ. Proc. Work Conf.) 9, 121-122.
Juskiewicz, T., and Kowalski, B. (1976). An investigation of the possible presence or formation of nitrosamines in animal feeds. IARC Sci. Publ. (N-Nitroso Compd. Environ. Proc. Work Conf.) 14, 375-393.
Mirvish, S.S. (1975). Blocking the formation of N-nitroso compounds with ascorbic acid in vitro and in vivo. Ann. N. Y. Acad. Sci. 258, 175-180.
Sander, J. (1967). [A method for the demonstration of nitrosamines.] [article in German]. Hoppe Seylers Z. Physiol. Chem. 348, 852-854.
Sander, J., Schweinsberg, F., and Menz, H.P. (1968). [Studies on the origin of carcinogenic nitrosamines in the stomach.] [article in German]. Hoppe Seylers Z. Physiol. Chem. 349, 1691-1697.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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