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EC number: 231-912-9 | CAS number: 7778-74-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish life cycle toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 September 1995 - 8 January 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Materials and methods are well described in the study.
- GLP compliance:
- no
- Vehicle:
- no
- Details on test solutions:
- For the experimental treatment the following concentrations were used: 10 mg/L propylthiouracil, 0.1 M NaOH (50 mL/10L) to increase the solubility of propylthiouracil and 0.01 or 0.05%, respectively.
- Test organisms (species):
- other: Lampetra appendix
- Details on test organisms:
- Lampetra appendix larvae and fish were collected from lakes in the area of Toronto, Canada from June 1995 till August 1996.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 117 d
- Remarks on exposure duration:
- 117 days in five treatments
- Test temperature:
- 16 - 21 °C
- Details on test conditions:
- The fish were held in static water tanks. The water was refreshed every two weeks and stock solution of potassium perchlorate was added after each refreshing.
- Key result
- Duration:
- 117 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: effect on metamorphosis
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the results of this study the LOEC can be stated as 0.01% (100 mg/L) referred to potassium perchlorate and 72 mg/L referred to the perchlorate anion.
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Materials and methods are well described in the study.
- GLP compliance:
- no
- Vehicle:
- no
- Details on test solutions:
- For the experiment 300 larvae were divided in 10 groups of 30 larvae each:
1. no treatment; 2. low dose of T3, thyroxine (0.5 mg/L); 3. high dose of T3, thyroxine (1 mg/L); 4. low dose of T4, triiodothyronine (0.25 mg/L); 5. high dose of T4, triiodothyronine (1 mg/L); 6. 0.05% of potassium perchlorate; 7. 0.05% of potassium perchlorate + low dose of T4; 8. 0.05% of potassium perchlorate and high dose of T4; 9. 0.05% of potassium perchlorate and low dose of T3; 10. 0.05% of potassium perchlorate and high dose of T3 - Test organisms (species):
- Petromyzon marinus
- Details on test organisms:
- Larvae of landlocked lamprey (petromyzon marinus) were collected in mid-September from Salmon River near Keeseville, NY, USA.
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 16 wk
- Remarks on exposure duration:
- tests were performed with 4, 8 and 16 weeks of treatment
- Test temperature:
- 15 - 18 °C
- Details on test conditions:
- Water was changed all 14 days.
- Key result
- Duration:
- 8 wk
- Dose descriptor:
- LOEC
- Effect conc.:
- 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: effect on metamorphosis
- Key result
- Duration:
- 8 wk
- Dose descriptor:
- LOEC
- Effect conc.:
- 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: organ weights
- Details on results:
- The effects of thyroid hormones and potassium perchlorate on petromyzon marinus were investigated.
The weight of liver and kidney and somatic indices were measured and the effects of inducing metamorphosis were determined after 4, 8 and 16 weeks of exposure.
Only one concentration (0.05% w/v) was tested. This induced effects on organ weights, somatic indices and metamorphosis after 8 weeks of exposure to potassium perchlorate. - Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the results of this study the LOEC can be stated as 0.05% (500 mg/L) referred to potassium perchlorate and 359 mg/L referred to the perchlorate anion.
Referenceopen allclose all
concentrations (nmol/L) of thyroxine (T4) and triiodothyronine (T3) in serum of larval and fish
larval, T4 | larval, T3 | metamorphosing, T4 | metamorphosing, T4 | |
control group | 32.82 | 28.48 | - | - |
NaOH | 28.45 | 26.60 | - | - |
KClO4 0.01% | 10.24 | 2.05 | 9.24 | 1.33 |
KClO4 0.05% | 11.85 | 1.44 | 8.01 | 1.18 |
propylthiouracil |
15.00 |
5.80 |
9.48 |
0.94 |
Description of key information
Based on the available studies a LOEC of 100 mg/L for potassium perchlorate can be stated.
The 12-week NOEC for Danio rerio derived from standard endpoints and whole-body T4-levels can be stated as 11.48 mg/L based on perchlorate anio and 16 mg/L calculated on potassium perchlorate.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 16 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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