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EC number: 249-385-9 | CAS number: 29043-70-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-01-14 to 1999-06-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a draft OECD test guideline, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline for Testing of Chemicals, Draft OECD Guideline, Dermal Delivery and Percutaneous Absorption: In Vitro Method, June 1996
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dimethylbis(octadecyloxy)silane
- EC Number:
- 249-385-9
- EC Name:
- Dimethylbis(octadecyloxy)silane
- Cas Number:
- 29043-70-7
- Molecular formula:
- C38H80O2Si
- IUPAC Name:
- dimethylbis(octadecyloxy)silane
- Test material form:
- other: solid
Constituent 1
Test animals
- Species:
- pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- n/a
Administration / exposure
- Vehicle:
- ethanol
- Duration of exposure:
- 24 hours
- Doses:
- - Actual doses: 3 mg/mL in 40 % ethanol
- Dose volume: 1 mL of test item in ethanol - No. of animals per group:
- n/a
- Control animals:
- yes
- Remarks:
- negative control: ethanol; positive control: caffeine
- Details on study design:
- DOSE PREPARATION
- Method for preparation of dose suspensions: test material was suspended in 40 % ethanol
- Method of storage: no data
APPLICATION OF DOSE: 3 mg/ml
VEHICLE
- Justification for use and choice of vehicle (if other than water): ethanol was chosen because of its solubility properties and non-toxicity to the skin
TEST SITE
- Preparation of test site: the skin was washed, cleaned and shaved from hair, then the skin was removed by dissection
- Area of exposure: eat skin
REMOVAL OF TEST SUBSTANCE
The test substance was applied to the skin throughout the skin penetration test
ANALYSIS
- Method: atom absorption spectroscopy (AAS)
SAMPLE PREPARATION
- Storage procedure: stored at -20 °C after collection, shipped at room temperature and stored at room temperature before analysis
- Preparation details:
SKIN INTEGRITY
- Conductivity across the skin was measured at each sampling time
- Skin damages are indicated by sudden increase in conductivity - Details on in vitro test system (if applicable):
- SKIN PREPARATION
- Source of skin: Rambaud slaughter house
- Ethical approval if human skin: not applicable
- Type of skin: porcine ear skin
- Preparative technique: the outer region of the ear was washed and cleaned, the hair was shaved and the skin was removed by dissection
- Thickness of skin (in mm): 0.5 mm
- Membrane integrity check: Integrity was monitored over the entire duration of the study by measuring conductivity across the skin at each sampling time. Skin damage is indicated by a sudden increase in conductivity or unsteady slopes of the measured values over time.
- Storage conditions: no data
- Justification of species, anatomical site and preparative technique: porcine skin has shown to give comparable results to those obtained from human skin.
PRINCIPLES OF ASSAY
The skin was mounted in a glass flow through diffusion chamber with a diameter of 1.135 cm and volume of 1 ml (donor chamber). The upper part was the donor chamber and the lower part-acceptor chamber. The acceptor chamber was filled with 40 % ethanol at the beginning of the experiment. Ethanol was pumped through the chambers using a 6-channel peristaltic pump with a flow rate of 1-2 ml/hour/chamber. The eluent of the acceptor chamber was collected in plastic vials, which were stored at -20°C until analysis. The donor chamber was filled with 3 mg/ml test material in 40 % ethanol and covered with paraffin. The whole system was set up in an incubator at 32°C. The collecting vials were changed at 0, 0.5, 1, 2, 4, 6, 8 and 24 hours. The rate of absorption was calculated by determination of the test substance concentration in the collecting vials.
Results and discussion
- Signs and symptoms of toxicity:
- not examined
- Dermal irritation:
- not examined
- Absorption in different matrices:
- - Receptor fluid, receptor chamber, donor chamber (in vitro test system): no relevant skin absorption was observed at any time point within the time frame of the experiments.
Percutaneous absorption
- Dose:
- 3 mg/ml
- Parameter:
- percentage
- Absorption:
- 0 %
- Remarks on result:
- other: 0, 0.5, 1, 2, 4, 6, 8 and 24 hours
- Remarks:
- No measurable penetration of the skin occurred at any time point within the time frame of the test.
Any other information on results incl. tables
Air bubbles were observed in all of the receptor chambers after 24 hours possibly blocking some of the skin area. However, since the conductivity across the skin was hardly affected, even after 24 hours, it was judged that the air bubbles did not have any relevant effect on the skin penetration.
Applicant's summary and conclusion
- Conclusions:
- In the skin permeability study for dimethylbis(octadecyloxy)silane, conducted according to a draft OECD Test Guideline, and in compliance with GLP, no skin penetration of the test substance was observed.
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