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EC number: 417-440-8 | CAS number: 2516-92-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- Version / remarks:
- November 1984
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,10-bis(2,2,6,6-tetramethyl-1-piperidinyloxy)-1,10-dioxodecane
- EC Number:
- 417-440-8
- EC Name:
- 1,10-bis(2,2,6,6-tetramethyl-1-piperidinyloxy)-1,10-dioxodecane
- Cas Number:
- 2516-92-9
- Molecular formula:
- C28 H50 N2 O6
- IUPAC Name:
- bis(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl) decanedioate
- Details on test material:
- Identification code (lab) = TKA 40075
Constituent 1
- Specific details on test material used for the study:
- Batch Ba #13
Test animals
- Species:
- rat
- Strain:
- other: HSD:(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Sprague Dawley, Inc., Houston, Texas
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: Young adult
- Weight at study initiation:
Males (199-226 g)
Females (197-211 g)
- Fasting period before study: at least 16 hours prior to treatment
- Housing:
Cage Type: Suspended, wire bottom, stainless steel
Housing: 1 per cage
Transfer to Clean Cages: Weekly
Litter Pan Lining: Paper and aspen beddmg
Litter Pan Lining Change: Three times weekly
Food: Purina Formulab Chow #5001; available ad libitum
Water Type: Tap, available ad libitum
Water System: Automatic
- Acclimation period: 1 week
IN-LIFE DATES: From: 06/10/1992 To: 24/10/1992
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
All animals were treated with 5050 mg/kg (12.6 ml/kg) of a 40.0% w/v concentration of the test material m deionized water.
MAXIMUM DOSE VOLUME APPLIED: 5050 mg/kg
- Doses:
- 5050 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Observations for mortality and signs of pharmacologic and/or toxicologic effects were made at least three tunes on the day of treatment and at least once daily thereafter for 14 days (day of treatmentconsideredDay0). Individualbodyweightswererecordedjustpriortotreatmentandon Days 7 and 14. A gross necropsy was conduaed on each animal at termination of the smdy.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 050 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: All animals appeared normal for the duration of the study.
- Gross pathology:
- The gross necropsy conduaed on all animals at termination of the smdy revealed no observable abnonnalities in any of the animals.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No animals died during the smdy. The acute oral LDjo for GUlO-415, as indicated by the data, is greater than 5050 mg/kg (12.6 ml/kg) when administered as a 40.0% w/v concentration in deionized water to albino rats.
- Executive summary:
An acute oral toxicity study (EPA 81 -1) was conducted on male and female albino rats using test material GU 10-415.
The test material was administered as a 40.0% w/v concentration in deionized water. Five males and five females were dosed at a level of 5050 mg/kg (12.6 ml/kg).
No animals died during the study. The acute oral LD50 for GU 10-415, as indicated by the data, is greater than 5050 mg/kg (12.6 ml/kg) deionized water to albino rats.
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