Registration Dossier
Registration Dossier
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EC number: 245-423-3 | CAS number: 23089-26-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2017-04-11 to 2017-06-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- Regulation (EC) 2016/266 method A.24
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 5.5
- Temp.:
- 25 °C
- pH:
- >= 5.9 - <= 6.2
- Details on results:
- The dead time t0 was determined to be 1.03 min. The log Pow of the test item was determined to be 5.5.
- Conclusions:
- The log Pow of the test item was determined to be 5.5.
- Executive summary:
A study was conducted in accordance with OECD TG 117 and Regulation (EC) No 440/2008 method A.24 to determine the partition coefficient of the test substance using the HPLC method. A solution of the test substance was prepared in the mobile phase. After equilibration of the HPLC system, the calibration mixture was injected first, followed by the test item solution, and the calibration mixture again, and once again the test item solution. The log Pow of the test item was determined to be 5.5.
Reference
Description of key information
The log Pow of the test item was determined to be 5.5.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5.5
- at the temperature of:
- 25 °C
Additional information
A study (reference 4.7-1) was conducted in accordance with OECD TG 117 and Regulation (EC) No 440/2008 method A.24 to determine the partition coefficient of the test substance using the HPLC method. A solution of the test substance was prepared in the mobile phase. After equilibration of the HPLC system, the calibration mixture was injected first, followed by the test item solution, and the calibration mixture again, and once again the test item solution. The log Pow of the test item was determined to be 5.5.
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
