3,7-dimethyloct-1-en-3-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

28th October 1988

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)

Deviations:

no

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3,7-dimethyloct-1-en-3-ol

EC Number:

242-358-2

EC Name:

3,7-dimethyloct-1-en-3-ol

Cas Number:

18479-49-7

Molecular formula:

C10H20O

IUPAC Name:

3,7-dimethyloct-1-en-3-ol

Test material form:

liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

10 animals (5 male, 5 females)
Animal Breeder: DR . K . THOMAE GMBH, D-7950 BIBERACH, FRG
Acclimatization period: at least for 1 week
n. of aniumal per cage: 5
Animals were housed in fully air-conditioned rooms. Temperature range: 20 - 24 Celsius degrees. Relative humidity: 30 - 70%
There were no deviations from these ranges which influenced the results of the study.
Day/Night rhythm: 12 h/12 h (6 .00am-6pm/ 6pm -6 am)
Diet: Kliba-Labordiaet 343, klimgentalmuehle AG CH-4303 Kaiseraugst, Switzerland ad libitum
Drinking water: Tap water ad libitum
Animal weights: animal of comparable weight (+/- 20% of the mean weight)
Feed was not provided to the animals starting from 16 hours before administration but water was maintained available ad libitum.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

CMC (carboxymethyl cellulose)

Details on oral exposure:

Reason for the vehicle: aqueous formulation corresponds to the physiological medium
Form of the administratio: emulsion

Doses:

Dose (mg/kg): 2000
Concentration (g/100 ml - W/V): 20
Administration volume (ml/kg): 10
Time of the day for the administration: in the morning

No. of animals per sex per dose:

10 animals in total (5 male, 5 females)

Details on study design:

number of animal per cage: 5
animal identification: by cage cards
Type of cage: STAINLESS STEEL WIRE MESH CAGES,TYPE DK-III ( BECKER & CO .,CASTROP-RAUXEL . FRG )
N. of animals per dose: 5 male animals and 5 female animals

Signs and symptons: OF SIGNS AND SYMPTOMS SEVERAL TIMES ON THE DAY OF ADMINISTRATION, AT LEAST ONCE EACH WORKDAY . CHECK FOR MORIBUND AND DEAD ANIMALS TWICE EACH WORKDAY AND ONCE ON HOLIDAYS .

Pathology: WITHDRAWAL OF FOOD ABOUT 16 HOURS BEFORE SACRIFICE WITH C02 ; THEN NECROPSV WITH GROSS-PATHOLOGICAL EXAMINATION . NECROPSY OF ALL ANIMALS THAT DIE AS EARLY AS POSSIBLE .

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Remarks on result:

not determinable due to absence of adverse toxic effects

Mortality:

Dead animals after 14 days: 0
Mortality: 0 %