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Diss Factsheets
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EC number: 228-327-6 | CAS number: 6227-20-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Test on three trophic levels are available. The LC/EC50 for all tests was > 98 mg/L
In a test according to OECD 203 (semi static with renewal every 24 hours, Envigo 2017), 7 rainbow trouts/concentration were exposed during 96 hours to 0 and 98 mg/L of the substance. The measured concentrations were between 98 and 99% of nominal. No mortality was observed at 1, 3, 6, 24, 48, 72 and 96 hours after the start of exposure in controls and at 98 mg/L. A slight staining on the fins and around the mouth was observed in fish exposed at 98 mg/L. The LC50 is therefore > 98 mg/L.
In a static test according to OECD 202 20 daphnids/concentration were exposed to 0, 6.25, 12.5, 25, 50 and 100 % of a saturated solution in Elendt M7 medium. Measured concentrations at 0, 50 and 100% were at 0 and 48 h: <LOQ and < LOQ (control), 48.7 and 48.9 mg/L (50%) and 98.3 and 99.2 mg/L (100%). At 100% 2/20 daphnids were found immobilised at the 48 hour observation. As this finding is within the criteria for a valid control (immobilisation maximum 10%), the NOEC is set at 98 mg/L (initial concentration). The 48 h EC50 for daphnia magna is >98 mg/L.
Lemna minor was exposed to an aqueous solution of the substance at concentrations of 1.0, 3.2, 10, 32 and 100 mg/L (three replicate flasks per concentration) for a period of 7 days, under constant illumination at a temperature of 24 ± 1 °C. The number of fronds in each control and treatment group was recorded on days 0, 3, 5 and 7 along with observations on plant development. Measured concentrations were 71 -103% of nominal. Effects on yield and growth rate were observed at 32 mg/L based on frond count and at 10 mg/L based on dry weight. The EC50 is > 100 mg/L and the NOEC is 3.2 mg/L (worst case on dry weight).
In a study according to OECD 209 (with 30 min exposure period) the substance did not inhibit the respiration of sludge at concentrations up to 10000 mg/L (Bayer 1998). When corrected for the active ingredient the EC50 is >500 mg/L. The NOEC is 500 mg/L (based on a.i.)
Additional information
The starting point for the derivation of the PNECwater will be 98 mg/L. No sensitivity difference between the species tested was observed.
The starting point for the derivation of the PNEC STP will be the EC50 of 500 mg/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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