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Diss Factsheets
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EC number: 213-903-1 | CAS number: 1064-48-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
LD50 = 5000 mg/kg body weight
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 2, 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted according to a method similiar to internationally accepted testing guidelines.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- mouse
- Strain:
- CF-1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: adult mice
-Mean body weight at study initiation: c.a 23 g
- Diet (e.g. ad libitum): Altromin No.1324 DK pellets
- Water : fresh water ad libitum
- Food deprivation: test substance was applied after food deprivation of 18 h.
- Acclimation period: the animales were acclimatized in test cage 5 days prior to application
ENVIRONMENTAL CONDITIONS
- Temperature (°C): room temperature was approx 22 °C
- Humidity (%): c.a. 50 %
- Photoperiod (hrs dark / hrs light): artificial lighting of the room varied every 12 hours - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: the product was provided as pure substance
- Purity:
MAXIMUM DOSE VOLUME APPLIED:
- Injectin volume: constant 20 cm3/kg - Doses:
- Single dose application : 5,000 mg/kg
- No. of animals per sex per dose:
- Ten mice were used
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes, withou any significant results
Other examinations performed:
- clinical signs n ot appliacble.
- Body weight: before application mean of 23.05 - Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animale died during the test duration
- Clinical signs:
- other: Not applicable
- Gross pathology:
- Without any significant finding
- Interpretation of results:
- other: Not classified according to the CLP Regulation (EC n. 1272/2008)
- Conclusions:
- LD 50 >5000 mg/kg body weight
- Executive summary:
Method:
Acute oral toxcicity was determined by a single oral appication via stomach tube in male mice, according to the a guideline similar to OECD 423.
Observation:
There were no symptoms of intoxication.
Results:
An LD50 value of > 5000 mg/kg body weight was found.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxcicity for Acid Black 001 was determined by a single oral appication via stomach tube in male mice, according to the a guideline similar to OECD 423. There were no symptoms of intoxication. An LD50 value of > 5000 mg/kg body weight was found.
Anotehr test used as supporting study shows an LD50 = 13913 mg/kg body weight.
Justification for classification or non-classification
Oral acute toxicity According to the CLP Regulation 1272/2008/EC, 3.1.2.1 section, substances can be allocated to one of four toxicity categories based on acute toxicity by the oral, dermal or inhalation route according to the numeric criteria shown in Table 3.1.1:
Oral (mg/kg bodyweight)
Category 1: LD50 ≤ 5
Category 2: 5 <LD50 ≤ 50
Category 3: 50 < LD50 ≤ 300
Category 4: 300 < LD50 ≤ 2 000
The acute oral median lethal dose LD50 in mice is > 5000 mg/kg body weight. The substance is not classified for oral toxicity because it doesn't meet the classification criteria of the CLP regulation n. 1272/2008.
Inhalation acute toxicity: No data avilable
Dermal acute toxicity: No data available
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