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EC number: 279-349-8 | CAS number: 79916-07-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- ACUTE EXPOSURE TO RHODAMINE B
- Author:
- Daniel J. Dire & Joseph A. Wilkinson
- Year:
- 1 987
- Bibliographic source:
- CLINICAL TOXICOLOGY, 2 5 ( 7 ) , 603-607 (1987)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute inhalation testing was conducted in individuals exposed through rhodamine B aerosols.
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthylium chloride
- EC Number:
- 201-383-9
- EC Name:
- 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthylium chloride
- Cas Number:
- 81-88-9
- Molecular formula:
- C28H31N2O3.Cl
- IUPAC Name:
- 9-(2-carboxyphenyl)-3,6-bis(diethylamino)xanthenium chloride
- Reference substance name:
- Rhodamine B
- IUPAC Name:
- Rhodamine B
- Test material form:
- other: Solid
- Details on test material:
- - Name of test material (as cited in study report): Rhodamine B
- Molecular formula (if other than submission substance): C28-H31-N2-O3.Cl
- Molecular weight (if other than submission substance): 479.017 g/mole
- Substance type: Organic
- Physical state: Solid
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Rhodamine B
- Molecular formula (if other than submission substance): C28-H31-N2-O3.Cl
- Molecular weight (if other than submission substance): 479.017 g/mole
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- other: Human
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Age at study initiation: 16 males of mean age 39 years (25-50) and one female 40 year old.
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- 26 minutes exposure to aerosolized Rhodamine B
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 26 min
- Remarks on duration:
- not specified
- Concentrations:
- No data available
- No. of animals per sex per dose:
- 17
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male/female
- Dose descriptor:
- other: EC
- Effect level:
- 4 530 000 other: mg
- Based on:
- test mat.
- Remarks on result:
- other: effect on clinicla sign
- Mortality:
- No data available
- Clinical signs:
- other: Burning of eyes, Excessive tearing, Nasal burning and etching, pain/Tightness in Chest, Rhinorhea, Cough, Dyspnea, Burniing of throat, Burning/Pruritic skin, Chest Burning, Headache and Nausea was observed in exposed patients.
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- not specified
Any other information on results incl. tables
Symptoms |
Number o f Patients |
Percent |
Burning of eyes |
14 |
82% |
Excessive tearing |
8 |
47% |
Nasal burning |
7 |
41% |
Nasal etching |
6 |
35% |
Chest pain/Tightness |
5 |
35% |
Rhinorhea |
5 |
29% |
Cough |
5 |
29% |
Dyspnea |
5 |
29% |
Burniing of throat |
4 |
24% |
Burning/Pruritic skin |
4 |
24% |
Chest Burning |
2 |
12% |
Headache |
1 |
6% |
Nausea |
1 |
6% |
No symptoms |
1 |
6% |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Conclusions:
- The most frequent symptoms were ocular and upper respiratory tract mucous membrane irritation. But all the symptoms resolved in 24 hours .No serious effects observed .Based on this the Effect concentration could be reported as approx (4.53kg) 4530000mg.
- Executive summary:
Approximately 10 lbs=4.53kg of Rhodamine B powder was spilled onto the floor of a vehicle maintenance shop. A cleanup crew began to sweep up the powder from the floor . This resulted in an aerosol of Rhodamine B dust that dispersed throughout the building contaminating the hair , skin, eyes, and clothing of most of the shop employees. 16 out of 17 of the patients (94%) complained of symptoms which are - One patient (6%) denied any symptoms despite being exposed to the dust for 15 minutes without a surgical mask. The most frequently reported symptom was burning of the eyes which occurred in 83% of the patients . Four of the patients (24%) were placed on humidified oxygen because of respiratory symptoms. Five o f the patients (29%) underwent irrigation of their eyes secondary to eye burning. After being discharged from the hospital and follow up is maintained . Ten of the patients (59%) reported that their symptoms had resolved within 4 hours of their exposure to the dust. One patient (6%) reported that his symptoms lasted 12 hours and 2 patients (12%) reported their symptoms lasted 24 hours. Three of the patients (18%) could not remember the duration of their symptoms. No serious effects observed .Based on this the Effect concentration could be reported as approx (4.53kg) 4530000mg.
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