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Diss Factsheets
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EC number: 203-430-9 | CAS number: 106-75-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study (OECD TG 403) with acceptable restrictions. Restriction: no analytical monitoring of the atmosphere concentration. Observation period not reported.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- : no analytical monitoring of the atmosphere concentration.
- GLP compliance:
- no
- Test type:
- other: Inhalation Risk Test
- Limit test:
- no
Test material
- Reference substance name:
- Oxydiethylene bis(chloroformate)
- EC Number:
- 203-430-9
- EC Name:
- Oxydiethylene bis(chloroformate)
- Cas Number:
- 106-75-2
- Molecular formula:
- C6H8Cl2O5
- IUPAC Name:
- oxydiethane-2,1-diyl dichlorocarbonate
- Details on test material:
- - Name of test material (as cited in study report): Diglycoldichlorkolensäureester
- Physical state: liquid
- Analytical purity: no data
- Other: pH 1; Melting point +4 °C; Boiling point 199 °C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean of 3 males and 3 females 170 g (experiment 1) 3 males and 3 females 156 g (experiment 2 same conditions)
ENVIRONMENTAL CONDITIONS
no data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- other: inhalation chamber
- Vehicle:
- other: air
- Details on inhalation exposure:
- Animals were exposed to a saturated atmosphere in an inhalation chamber. Atmosphere generation: dynamic. Air was conducted through a 5-cm
layer of TS in a fritted wash bottle. Nominal concentration was 0.0875 mg/L - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- saturated atmosphere
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: mean body weight prior to exposure and at termination of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- none
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 0.087 mg/L air (nominal)
- Exp. duration:
- 8 h
- Mortality:
- no deaths
- Clinical signs:
- other: Initially attempts to escape; slight irritation of the mucosa.
- Body weight:
- meaan body weight development was positive.
day 0: mean of 3 males and 3 females 170 g (experiment 1); 3 males and 3 females 156 g (experiment 2 same conditions)
day 7: mean of 3 males and 3 females 187 g (experiment 1) ; 3 males and 3 females 170 g (experiment 2 same conditions) - Gross pathology:
- Necropsy findings: 2 cases of chronic bronchitis, 1 case of bronchiectasia.
Any other information on results incl. tables
Mortality:
---------------------------
Exposure Animals
period dead/exposed
---------------------------
8 h 0/12
---------------------------
Signs of toxicity: Initially attempts to escape; slight irritation of the mucosa.
Necropsy findings:
2 cases of chronic bronchitis, 1 case of bronchiectasia.Applicant's summary and conclusion
- Conclusions:
- According to OECD TG 403 there is no likely inhalation hazard under normal conditions of exposure.
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