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EC number: 259-627-5 | CAS number: 55406-53-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in soil
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in soil: simulation testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989-08-08 to 1992-05-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: U. S. EPA Pesticide Assessment Guidelines Subdivision N, Section 162-1
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Agriculture Canada Trade Memorandum T-1-255
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- laboratory
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: N.J. L7-93; N.J. AS-2; 30-142-A
SOURCE OF TEST MATERIAL RADIOLABELLED
- Source and lot/batch No.of test material: NSN/1/77/1
- Radiochemical purity: 99.4 % - Radiolabelling:
- yes
- Oxygen conditions:
- aerobic
- Soil classification:
- not specified
- Year:
- 1 991
- Soil type:
- loam
- % Clay:
- 14
- % Silt:
- 40
- % Sand:
- 46
- % Org. C:
- 1.57
- pH:
- 6.1
- CEC:
- 10.1 meq/100 g soil d.w.
- Details on soil characteristics:
- SOIL COLLECTION AND STORAGE
- Geographic location: Missouri, U. S. A.
- Pesticide use history at the collection site: No pesticides were applied to this soil during the four year period prior to sampling
- Soil preparation: 2 mm sieved, connected to a moist air saturator prior to use
PROPERTIES OF THE SOILS
#1 and #2 refers to the nonsterile soil; #3 refers to sterile soil - Soil No.:
- #1
- Duration:
- 245 d
- Soil No.:
- #2
- Duration:
- 14 d
- Soil No.:
- #3
- Duration:
- 28 d
- Initial conc.:
- > 0.87 - < 1.03 ppm
- Based on:
- other: Fortification level ranges
- Parameter followed for biodegradation estimation:
- CO2 evolution
- radiochem. meas.
- Soil No.:
- #1
- Temp.:
- 22 °C
- Soil No.:
- #2
- Temp.:
- 5 °C
- Soil No.:
- #3
- Temp.:
- 22 °C
- Details on experimental conditions:
- 1. EXPERIMENTAL DESIGN
- Soil preincubation condition: non-sterile samples were allowed to acclimate to the test conditions for at least 5 days prioir treatment
- Soil condition: fresh
- Soil amount 250 g/replicate
- Control conditions: sterile/non-sterile
- Test apparatus: sidearm filter flasks were placed in an environmental chamber with polyurethane foam plug placed on top
Test material application
- Volume of test solution used/treatment: 2 mL of fortifications solution were added to each sample
- Application method: incorporated with a spatula
Any indication of the test material adsorbing to the walls of the test apparatus: none
Experimental conditions
- Moisture maintenance method: soil moisture was adjusted to 75 % of field capacity at monthly intervals
- Continuous darkness: No
2. SAMPLING DETAILS
- Sampling intervals:
Duplicate samples were taken at each specified interval:
Test A (Nonsterile, 22°C):
0, 3, 6, and 12 hours, 1, 2, 4, 7, 11, 21 and 245 days post-treatment.
Test B (Nonsterile, 5°C):
0, 3, 6, and 12 hours, 1, 2, 3, 4, 7 and 14 days post-treatment.
Test C (Sterile, 22°C):
0, 1, 4 and 28 days post-treatment. - Soil No.:
- #1
- Remarks on result:
- other: 89 to 105.2 %
- Soil No.:
- #2
- Remarks on result:
- other: 91.6 to 108.0 %
- Soil No.:
- #3
- Remarks on result:
- other: 100.0 to 104.4 %
- Key result
- Soil No.:
- #1
- DT50:
- 2.13 h
- Type:
- (pseudo-)first order (= half-life)
- Temp.:
- 22 °C
- Key result
- Soil No.:
- #2
- DT50:
- 8.6 h
- Type:
- (pseudo-)first order (= half-life)
- Temp.:
- 5 °C
- Key result
- Soil No.:
- #3
- DT50:
- 4.3 d
- Type:
- (pseudo-)first order (= half-life)
- Temp.:
- 22 °C
- Remarks on result:
- other: sterile soil
- Transformation products:
- yes
- No.:
- #1
- Evaporation of parent compound:
- no
- Volatile metabolites:
- no
- Conclusions:
- The test item was rapidly degraded under nonsterile aerobic soil conditions with half-life values of 2.13 and 8.60 hours at 22 and 5 °C, respectively. Propargyl butyl carbamate was the primary soil metabolite formed. Propargyl butyl carbamate (resulting from the test item application) was readily mineralized in nonsterile samples maintained at 22 °C. Mineralization rates were significantly lower at 5 °C. Test item degradation in soil was primarily microbially mediated but nonbiological mechanisms may contribute to the degradative process.
- Executive summary:
A laboratory study was performed to investigate the aerobic soil metabolism of the test item in a Blackoar loam soil at temperatures of 22 ± 2 °C and 5 ± 3 °C. The test item was rapidly degraded in soil at 22 °C with a half-life of 2.13 hours. The primary soil metabolite was propargyl butyl carbamate. Propargyl butyl carbamate also was readily degraded in soil at 22 °C with a half-life of 4.30 days. Test item degradation was slowed at 5 °C resulting in a soil half-life of 8.60 hours. The rate of propargyl butyl carbamate degradation decreased to a greater extent than that of the test item itself as temperature decreased from 22 to 5 °C. Fourteen days after treatment, greater than 60% of the applied 14C had been mineralized to 14CO2 at 22 °C whereas less than 5% had been mineralized at 5 °C. The test item and propargyl butyl carbamate degradation in soil is primarily microbially mediated but nonbiological processes may be involved.
Reference
Description of key information
The test item was rapidly degraded under nonsterile aerobic soil conditions with half-life values of 2.13 and 8.60 hours at 22 and 5 °C, respectively. Propargyl butyl carbamate was the primary soil metabolite formed. Propargyl butyl carbamate (resulting from the test item application) was readily mineralized in nonsterile samples maintained at 22 °C. Mineralization rates were significantly lower at 5 °C. Test item degradation in soil was primarily microbially mediated but nonbiological mechanisms may contribute to the degradative process.
Key value for chemical safety assessment
- Half-life in soil:
- 2.1 h
- at the temperature of:
- 22 °C
Additional information
A laboratory study was performed to investigate the aerobic soil metabolism of the test item in a Blackoar loam soil at temperatures of 22 ± 2 °C and 5 ± 3 °C. The test item was rapidly degraded in soil at 22 °C with a half-life of 2.13 hours. The primary soil metabolite was propargyl butyl carbamate. Propargyl butyl carbamate also was readily degraded in soil at 22 °C with a half-life of 4.30 days. Test item degradation was slowed at 5 °C resulting in a soil half-life of 8.60 hours. The rate of propargyl butyl carbamate degradation decreased to a greater extent than that of the test item itself as temperature decreased from 22 to 5 °C. Fourteen days after treatment, greater than 60% of the applied 14C had been mineralized to 14CO2 at 22 °C whereas less than 5% had been mineralized at 5 °C. The test item and propargyl butyl carbamate degradation in soil is primarily microbially mediated but nonbiological processes may be involved.
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