Registration Dossier
Registration Dossier
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EC number: 236-164-7 | CAS number: 13197-76-7
Endpoint summary
Administrative data
Description of key information
Fish
The 96 h LC50 for Danio rerio exposed to Betadet S-20 was determined to be 184 mg/L with a corresponding NOEC of 168.2 mg/L. The LC50 equates to 55.2 mg principal constituent/L after correction for the p.c. content of the tested batch of Betadet S-20.
Daphnia
The key short-term toxicity to aquatic invertebrates study resulted in 24-h and 48-h EC50 values of 71.4 and 36.6 mg/L, respectively for Daphnia magna exposed to A-20HD. Test item concentration was corrected for its purity. The study met all of the validity criteria prescribed by the standard OECD 202 Guideline and is considered to be reliable.
A supporting study resulted in a 24-h EC50 of Betadet S-20 of >30 mg/L (the highest nominal concentration tested) and a 48-h EC50 of 16 mg/L, with a corresponding NOEC of 6.0 mg/L. The 48 h EC50 equates to 4.8 mg principal constituent/L, based on the 30% (w/w) p.c. content of the tested batch of Betadet S-20. However, given that no chemical analysis of test concentrations was included, this study is considered unreliable.
Algae
The 72 h ErC50 of Betadet S-20 based on inhibition of the growth rate of Pseudokirchneriella subcapitata was calculated to be 4.58 mg/L (95% confidence limit: 4.34 to 4.83 mg/L), expressed in terms of analytically verified nominal concentrations of the principal constituent. The corresponding NOErC (0 -72h) was 0.508 mg principal constituent/L.
Microorganisms
An assessment of the ready biodegradability of Betadet S-20 was performed with the test substance applied at a concentration of 10 mg/L in the Closed Bottle Test (OECD TG 301D). The test was inoculated with a low density of activated sludge microorganisms obtained from the secondary effluent of a STP that received sewage of predominantly domestic origin. The test design included a toxicity control that comprised a mixture of Betadet S-20 (10 mg/L) and the readily biodegradable reference compound sodium benzoate. The toxicity control response showed no evidence of suppression of the microbial utilisation of Na benzoate by the presence of Betadet S-20, when compared to the parallel performance of the reference treatment dosed with Na benzoate alone. These findings support a microbial NOEC of 10 mg Betadet S-20/L, which equates to 3.0 mg principal constituent/L, based on the 30% (w/w) p.c. content of the tested batch of Betadet S-20.
Additional information
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