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Diss Factsheets
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EC number: 262-114-9 | CAS number: 60239-68-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Principles of method if other than guideline:
- Groups of 10 male NMRI mice were administered the test substance diluted in water at concentrations of 800 to 4200 mg/kg bw. Animals were then observed for clinical signs and mortality.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Body weight: ca. 20 g
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- From 0 to 4200 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Necropsy of survivors performed: no
- Other examinations performed: clinical signs - Statistics:
- None
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 700 mg/kg bw
- Based on:
- test mat.
- Mortality:
- As of 2000 mg/kg bw
- Clinical signs:
- Lying on the side or the back, cramps, uneven breathing, no reaction to noise or other stimulations.
Mortality was observed from 0.5 to 4 h after exposure. - Body weight:
- Not evaluated.
- Gross pathology:
- Not evaluated.
- Other findings:
- Not evaluated.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the study conditions, the LD50 of the test substance in mouse was determined to be 2700 mg/kg bw.
- Executive summary:
A study was conducted to determine the oral acute toxicity of the test substance, C11-unsatd. DEA (purity not specified). Groups of 10 male NMRI mice received a single dose of the test substance diluted in water by gavage at concentrations ranging from 800 to 4200 mg/kg bw. The animals were then observed for clinical signs and mortality. Under the study conditions, the LD50 of the test substance in mice was determined to be 2700 mg/kg bw (Ihlow, 1963).
Reference
None.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 700 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
The available data for the test substance indicates a low potential for acute toxicity (oral LD50 >2,000 mg/kg bw). The substance therefore does not meet the requirement for classification according to CLP (EC 1272/2008) criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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