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EC number: 219-247-2 | CAS number: 2393-23-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- for Read across substance
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two short term toxicity study of fish for the test chemical :
1.To evaluate toxicity of test material on Lipomyces starkeyi IFO10381
2.Aim of this study was to assess the effect of test chemical on the growth of microorganisms. - GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: 4-Methoxybenzylamine
- IUPAC name: p-anisylamine
- Molecular formula: C8H11NO
- Molecular weight: 137.181 g/mole
- Smiles :O(c1ccc(cc1)CN)C
- Inchl: 1S/C8H11NO/c1-10-8-4-2-7(6-9)3-5-8/h2-5H,6,9H2,1H3
- Substance type: Organic
- Physical state: Liquid (Colorless to pale yellow) - Analytical monitoring:
- not specified
- Details on test solutions:
- 1.The compound was used as a methanol solution to produce final concentrations of 20 or 200 mg/L compound and 1% (v/v) methanol.
- Test organisms (species):
- other: 1.Lipomyces starkeyi IFO10381 , 2.Tetrahymena pyriformis
- Details on inoculum:
- 1.Oleaginous yeast, Lipomyces starkeyi IFO10381 (IFO, Osaka, Japan) was maintained on YM agar at 25 °C. One loopful of yeast well grown on a YM agar slant was inoculated into 5 mL of YM broth and cultivated with 120 rpm rotary shaking at 27 °C for 2 days. The precultured broth was inoculated with 1% (v/v) inoculum into the MLA broth
2.- Laboratory culture: Exponential growth phase (log) culture were used - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 7 d
- Test temperature:
- 1 and 2 . 27 °C
- pH:
- 2)7.35
- Nominal and measured concentrations:
- 1)20 and 200 mg/L
- Details on test conditions:
- 1) The compound as a methanol solution was added to 5 mL of broth in a test tube to produce final concentrations of 20 or 200 mg/L compound and 1% (v/v) methanol at the start of the culture. As a control, 1% methanol was added to the broth. Yeasts were cultivated using a rotary shaker (120 rpm) at 27 °C for 7 days
2) Details on test conditions
TEST SYSTEM
- No. of vessels per concentration (replicates): ≥ 3 - Reference substance (positive control):
- not specified
- Duration:
- 7 d
- Dose descriptor:
- other: EC14
- Effect conc.:
- 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Read across 1
- Duration:
- 48 h
- Dose descriptor:
- IC50
- Effect conc.:
- 157 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Read across 2
- Validity criteria fulfilled:
- not specified
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity to microorganism of the test chemical 4-Methoxybenzylamine (2393 -23 -9).The studies are as mentioned below:
1.Antifungal activity of test material was tested at the dose concentrations of 20 and 200 mg/L on the fungi Lipomyces starkeyi IFO10381 for a duration of 7 days. The substance inhibited fungal growth by 14% at both concentrations.
2.Aim of this study was to assess the effect of test chemical on the growth of microorganisms Tetrahymena pyriformis (Ciliate). Test conducted under the static system for total exposure period of 48 hrs. ≥ 3 replicates were used. Based on the population growth rate inhibition of test organism Tetrahymena pyriformis (Ciliate) due to the test chemical , the IC50 was determine to be 157 mg/l. Thus based on the IC50, test chemical was consider as nontoxic.
Thus, based on the above summarised studies, 4-Methoxybenzylamine and it’s structurally and functionally similar read across substance, it can be concluded that effect concetration value is in the range 157- 200 mg/l
Reference
Description of key information
Toxicity to microorganisms:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity to microorganism of the test chemical 4-Methoxybenzylamine (2393 -23 -9).The studies are as mentioned below:
1.Antifungal activity of test material was tested at the dose concentrations of 20 and 200 mg/L on the fungi Lipomyces starkeyi IFO10381 for a duration of 7 days. The substance inhibited fungal growth by 14% at both concentrations.
2.Aim of this study was to assess the effect of test chemical on the growth of microorganisms Tetrahymena pyriformis (Ciliate). Test conducted under the static system for total exposure period of 48 hrs. ≥ 3 replicates were used. Based on the population growth rate inhibition of test organism Tetrahymena pyriformis (Ciliate) due to the test chemical , the IC50 was determine to be 157 mg/l. Thus based on the IC50, test chemical was consider as nontoxic.
Thus, based on the above summarised studies, 4-Methoxybenzylamine and it’s structurally and functionally similar read across substance, it can be concluded that effect concetration value is in the range 157- 200 mg/l
Key value for chemical safety assessment
- EC50 for microorganisms:
- 200 mg/L
Additional information
Toxicity to microorganisms:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity to microorganism of the test chemical 4-Methoxybenzylamine (2393 -23 -9).The studies are as mentioned below:
1.Antifungal activity of test material was tested at the dose concentrations of 20 and 200 mg/L on the fungi Lipomyces starkeyi IFO10381 for a duration of 7 days. The substance inhibited fungal growth by 14% at both concentrations.
2.Aim of this study was to assess the effect of test chemical on the growth of microorganisms Tetrahymena pyriformis (Ciliate). Test conducted under the static system for total exposure period of 48 hrs. ≥ 3 replicates were used. Based on the population growth rate inhibition of test organism Tetrahymena pyriformis (Ciliate) due to the test chemical , the IC50 was determine to be 157 mg/l. Thus based on the IC50, test chemical was consider as nontoxic.
Thus, based on the above summarised studies, 4-Methoxybenzylamine and it’s structurally and functionally similar read across substance, it can be concluded that effect concetration value is in the range 157- 200 mg/l
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