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EC number: 202-181-3 | CAS number: 92-71-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24th July 2017 to the 20th November 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
Test material
- Reference substance name:
- 2,5-diphenyloxazole
- EC Number:
- 202-181-3
- EC Name:
- 2,5-diphenyloxazole
- Cas Number:
- 92-71-7
- Molecular formula:
- C15H11NO
- IUPAC Name:
- 2,5-diphenyl-1,3-oxazole
- Test material form:
- solid: crystalline
- Details on test material:
- Expiry date:01 February 2021
Storage conditions: Room temperature in the dark
Batch 21-16131
1
- Specific details on test material used for the study:
- Identification:
2,5-diphenyloxazole
Appearance/Physical state:
White crystalline powder
Batch:
21-16131
Purity:
99.9%
Expiry date:
01 February 2021
Storage conditions:
Room temperature, in the dark
Results and discussion
Water solubility
- Key result
- Water solubility:
- >= 0.001 - <= 0.001 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Incubation duration:
- ca. 3 h
- Temp.:
- 20 °C
- pH:
- ca. 5.7
Any other information on results incl. tables
The concentration of test item in the sample solutions was determined by high performance
liquid chromatography (HPLC).
Samples
An aliquot of each sample solution was diluted by a factor of 2 using methanol.
Standards
Duplicate standard solutions of test item were prepared in methanol: purified water (1:1 v/v)
at a nominal concentration of 0.25 mg/L.
Matrix blank
Methanol: purified water (1:1 v/v).
Analysis
The standard and sample solutions were analyzed by HPLC using the following conditions:
HPLC System : Agilent Technologies 1200, incorporating workstation
and autosampler
Detector type : variable wavelength (VW)
Column : Phenomenex Kinetix EVO C18 100Å (150 x 4.6 mm id)
Column temperature : 30 °C
Mobile phase : Methanol: purified water (75:25 v/v)
Flow-rate : 1.0 mL/min
Injection volume : 100 μL
VW detector wavelength : 303 nm
Retention time : ~ 4.0 mins
Applicant's summary and conclusion
- Conclusions:
- The substance, 2,5-diphenyloxazole, water solubility was studied in accordance with EC Method A.6 and OECD Method 109 via a GLP-certified laboratory. The study used the column elution method with HPLC analysis and determined that the substance water solubility was 0.000625 g/L at 20.0 ± 0.5 °C.
- Executive summary:
The substance, 2,5-diphenyloxazole, water solubility was studied in accordance with EC Method A.6 and OECD Method 109 via a GLP-certified laboratory. The column elution apparatus was set up in duplicate (Systems A and B). Each system consisted of a glass micro-column fitted with a plug of glass wool, connected to a recirculating pump and a reservoir holding approximately 500 mL of purified water. Temperature was thermostatically controlled via circulating water from a water bath fitted with a cooling coil and maintained at 20.0 ± 0.5 °C. An aliquot (0.1163 g) of test item was dispersed in 20 mL of dichloromethane. Glass beads (approximately 1.0 g) were added and the solvent removed using a rotary evaporator (35 °C).
The systems were flushed with purified water for approximately 3 hours which was then discarded. The reservoirs were re-filled with fresh purified water and approximately half the coated glass beads loaded into each micro-column. After allowing the coated beads to soak for at least 2 hours, the water in the column was run to waste. The recirculating pumps were switched on and approximately 30 mL of column eluate collected to determine the flow rate.
The mean peak area and concentration of each standard solution were plotted on a calibration curve and the sample concentration interpolated from the curve. The values were then corrected for the dilution factor. The study used the column elution method with HPLC analysis and determined that the substance water solubility was 0.000625 g/L at 20.0 ± 0.5 °C.
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