Registration Dossier
Registration Dossier
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EC number: 235-920-3 | CAS number: 13047-13-7
Endpoint summary
Administrative data
Description of key information
In a test according to OECD 202 with a semi-static design (renewal after 24 h), daphnids were exposed to the test substance at 2.2, 4.6, 10, 22, 46 and 100 mg/L (nominal) for 48 hours. Analyses of the fresh and old solutions showed that concentrations dropped to 18 -29% of initial. The time weight average concentrations were 0.85, 1.7, 3.8, 8.4, 20 and 44 mg/L. Immobilisation was observed at 3.8 mg/L and above. The EC50 was 4.0 mg/L (Charles River 2018).
Lemna minor colonies were exposed to a control and substance concentrations of 1.0, 3.2, 10, 32 and 100 mg/L. The total exposure period was 7 days and test solutions were renewed daily. The actual concentrations measured in the freshly prepared solutions and aged soutions showed a time weighed average exposure concentrations were 0.80, 2.6, 7.5, 24 and 88 mg/L. A dose-related response were observed for all relevant endpoints (Charles River 2018).
The substance reduced growth rate and inhibited the yield of this fresh water plant species significantly at 7.5 mg/L (LOEC) when calculated based on frond number and at 0.80 mg/L when calculated based on biomass. The NOEC for growth rate reduction and yield inhibition was 2.6 mg/L (fronds) and <0.80 mg/L (biomass).
The 48 h LC50 in Goldenorfe is 35 mg/L in a limited reported test (Fresenius 1992). For pseudomonas putida the EC50 as derived is 480 mg/L (Fresenius 1993).
Additional information
The substance does not need to be classified for aquatic toxicity although the lowest NOEC is < 1 mg/L (EC10 growth rate 0.55 mg/L ) (Charles River 2018)and the substance is not rapidly biodegradable (Charles River 2017). The substance does, however have a low logKow 0.18 and hydrolyses when in contact with aqueous solutions (Charles River 2018 and Agfa 2017 (see section 4.27). In addition there are indications that the substance may be inherently biodegradable (Fresenius 1992).
Therefore it is concluded that no classification is required according to EC 1272/2008 (CLP regulation).
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