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Diss Factsheets
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EC number: 214-897-3 | CAS number: 1207-75-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 April 2017 - 19 April 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 13320-1
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 187
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Chilworth Technology Ltd SOP n°417
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- 3-(2-hydroxyethyl)-1H,3H-quinazoline-2,4-dione
- EC Number:
- 214-897-3
- EC Name:
- 3-(2-hydroxyethyl)-1H,3H-quinazoline-2,4-dione
- Cas Number:
- 1207-75-6
- Molecular formula:
- C10H10N2O3
- IUPAC Name:
- 3-(2-hydroxyethyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Batch n°: I16JB3859
- Expiration date: 15 October 2018
- Purity: 99.4% (based on acid titration)
- Storage condition of test material: at room temperature
Results and discussion
- Mass median aerodynamic diameter:
- 109.451 µm
- Geometric standard deviation:
- >= 3.432 - <= 3.493
Particle sizeopen allclose all
- Percentile:
- D10
- Mean:
- 18.066 µm
- St. dev.:
- 0.167
- Remarks on result:
- other: Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.
- Key result
- Percentile:
- D50
- Mean:
- 89.666 µm
- St. dev.:
- 1.213
- Remarks on result:
- other: Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.
- Percentile:
- D90
- Mean:
- 300.004 µm
- St. dev.:
- 2.807
- Remarks on result:
- other: Average result is calculated from the entirety of data captured in each run and is not a simple arithmetic mean.
Any other information on results incl. tables
Visual Microscope Analysis
(1) Standard visual observation: sample observed to be medium to fine white powder with clusters.
(2) Observation using 3.2 objective lens: particles appeared to be irregular shaped crystals (smallest +/- 6 µm and largest +/- 304 µm)
(3) Observation using 40 objective lens: sample was observed to be made up of single crystalline particles.
Laser Diffraction Particle Size Analysis
Using the identified parameters, the particle size was analysed over the range 0.02 μm to 2000 μm.
The average Volume weighted Mean was 128.117 µm and the mode was 160.021 µm. The Coefficient of Variation for d50 was <3%; d10 and d90 were <5%. Thus the repeatability of the characteristic particles in the size distribution was within the acceptable limits according to the ISO 13320-1 test standard.
Applicant's summary and conclusion
- Conclusions:
- Visual examination using 3.2 objective lens showed irregular shaped crystals between approximately 6 µm and 304 µm.
The particle size distribution of T001200 determined by the laser diffraction method led to the conclusion that the average volume weighted mean based on 5 runs was 128.117 µm and the Mass Median Aerodynamic Diameter (MMAD) based on 5 runs was 109.451 µm, whereas the average D10, D50 and the D90 were determined to be 18.066 µm, 89.666 µm and 300.004 µm, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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