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EC number: 237-393-5 | CAS number: 13770-61-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- briefly documented (only Results tables in English) but acceptable for assessment.
- Justification for type of information:
- see section 13 in IUCLID for read-across justification report
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Data book for mutagenicity tests on chemicals in bacteria
- Author:
- Ishidate M
- Year:
- 1 991
- Bibliographic source:
- LIC/Tokyo
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- JAPAN: Guidelines for Screening Mutagenicity Testing Of Chemicals
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Indium trichloride
- EC Number:
- 233-043-0
- EC Name:
- Indium trichloride
- Cas Number:
- 10025-82-8
- Molecular formula:
- Cl3In
- IUPAC Name:
- indium trichloride
- Details on test material:
- - Name of test substance: indium trichloride InCl3 (111In)
- CAS No.: 10025-82-8
- Molecular weight: 221.18
Constituent 1
Method
- Target gene:
- not applicable
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium, other: S. typhimurium TA 100, TA 2637, TA 94, TA 98
- Species / strain / cell type:
- E. coli, other: E. coli WP2µvrA+, E. coli WP2µvrA-
- Metabolic activation:
- with and without
- Metabolic activation system:
- induced rat liver S9 mix
- Test concentrations with justification for top dose:
- 1.25, 2.5, 5.0, 12.5, 25.0, 50.0 µCi/plate
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: distilled water
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Remarks:
- With S9 mix: 2-AA (100 μg/plate, strains TA 100, TA 2637, TA 94, TA 98 and WP2µvrA-. Without S9 mix: AF-2 (0.02 μg/plate, strains TA 100, TA 98 and WP2µvrA-), ICR-191 (5 μg/plate, strain TA 2637), MMC (10 μg/plate, strain TA 94)
- Positive control substance:
- furylfuramide
- mitomycin C
- other: 2-AA (2-aminoanthracene), ICR-191 (acridine mutagen)
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: preincubation
DURATION
- Preincubation period: 20min 37°C
NUMBER OF REPLICATIONS:2 - Evaluation criteria:
- no information
- Statistics:
- not available
Results and discussion
Test resultsopen allclose all
- Key result
- Species / strain:
- S. typhimurium, other: S. typhimurium TA 100, TA 2637, TA 94, TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Key result
- Species / strain:
- E. coli, other: E. coli WP2µvrA+, E. coli WP2µvrA-
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Additional information on results:
- none
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Conclusions:
- The test material was considered to be non-mutagenic for all the used bacterial strains (Salmonella typhimurium as well as Escherichia coli) with as well as without metabolic activation
- Executive summary:
A study was conducted to determine the potential mutagenicity of the test material using bacterial reverse mutation assay (e.g. Ames test).
No significant increases in the frequency of revertant colonies were recorded at any dose level.
The test material was considered to be non-mutagenic under the conditions of this test.
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