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Diss Factsheets
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EC number: 204-535-2 | CAS number: 122-34-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: "Appraisal of the safety of chemicals in Foods, Drugs and Cosmetics" by the Staff of the Division of Pharmacology, FDA, 1959 and OECD Guidelines for Toxicology of Chemicals, 1981
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- Although the study predates GLP, the appendix in the report states that the experiment was carried out in accordance with GLP and OECD Guidelines.
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Simazine
- EC Number:
- 204-535-2
- EC Name:
- Simazine
- Cas Number:
- 122-34-9
- Molecular formula:
- C7H12ClN5
- IUPAC Name:
- 6-chloro-N2,N4-diethyl-1,3,5-triazine-2,4-diamine
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- - Test material: Simazine Technical
- Description: White powder
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Paderborn, Germany
- Weight at study initiation: 200 g (mean bodyweight)
- Fasting period before study: 16 hours
- Housing: single cages
- Diet (e.g. ad libitum): Laboratory standard diet
- Water: available ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C ± 1°C
- Humidity (%): 50 - 60%
- Photoperiod (hrs dark / hrs light): 12 hours light/ 12 hours dark
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 1%
MAXIMUM DOSE VOLUME APPLIED: 2.06 mL - Doses:
- 2500, 5000 and 7500 mg/kg bw
- No. of animals per sex per dose:
- 5 rats per sex per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Bodyweights were measured at the start and end of the experiment. Mortalities were assessed 24 hours, 48 hours and 7 days after exposure. Clinical observations were made 7 and 14 days after exposure.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopic analysis
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 7 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortalities occurred during the study.
- Clinical signs:
- In all dosage groups, the preparation caused slight apathy, reduced frequency of respiration and diminished readiness for reflexing, 10-24 hours post application. After 7 days, no remarkable symptoms were observed.
- Body weight:
- All animals showed a slight reduction in bodyweight compared to normal gains within the laboratory.
- Gross pathology:
- Slight hyperaemia of the gastro-intestinal tract was observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No mortalities were observed throughout the study. The LD50 for acute oral toxicity is therefore >7500 mg/kg bw.
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