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EC number: 812-925-4 | CAS number: 1639345-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 5, 2016 - March 14, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Version / remarks:
- adopted 23. Mar. 2006, Annex 5 corrected: 28 July 2011
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4-[fluoro(dimethyl)silyl]butanenitrile
- EC Number:
- 812-925-4
- Cas Number:
- 1639345-42-8
- Molecular formula:
- C6H12FNSi
- IUPAC Name:
- 4-[fluoro(dimethyl)silyl]butanenitrile
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- During non GLP-pre-tests and this study the test item was obviously not soluble at the highest test item concentration of 100 mg/L. Therefore the water-accommodated fractions
(WAF) were prepared for the test for each concentration individually. This was done by weighing each nominal load, adding the corresponding amount of demineralised water and
shaking vigorously for 23 hours. The resulting solutions were filtrated through 0.45 μm PTFE filters. After filtration, the required amounts of minerals were added.
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- TEST ORGANISM
-Genus: Desmodesmus
-Species: subspicatus
-SAG Strain Number: 86.81
-Taxonomic position: Chlorophyta - Chlorophyceae
- Source (laboratory, culture collection): MBM Sciencebridge GmbH (Institut für Pflanzenphysiologie of Universität Göttingen)
- Method of cultivation: The algae are kept as stock culture on solid agar at 2 - 8 °C. From the stock culture, a permanent culture was prepared. From an aliquot of the permanent culture, the pre-culture was prepared.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
Test conditions
- Hardness:
- not mentioned in the report
- Test temperature:
- 22.4 – 22.6 °C
- pH:
- blank control, 4.6 / 10 / 22 / 46 mg/L nominal concentration:7.1 - 7.7
100 mg/L nominal concentration:4.4 - 5.0 - Dissolved oxygen:
- not mentioned in the report
- Salinity:
- not applicable
- Conductivity:
- not mentioned in the report
- Nominal and measured concentrations:
- The measured concentrations lay between 75 % and 96 % of the nominal concentrations at the beginning of the test and between 96 % and 101 % of the nominal concentrations at the end of the test. Only in the lowest concentration the measured concentration was lower than 80 % of the nominal concentration. As this treatment was not necessary for evaluation of the biological results it was excluded from the determination of the biological results. Therefore, the determination of the results was based on the nominal concentrations.
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass flasks, total volume 65 mL
- Initial cells density: 4*10^3 cells/mL
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 6
OTHER TEST CONDITIONS
- Sterile test conditions: yes
- Adjustment of pH: no
- Light intensity and quality: 4500 Lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Determination of cell concentrations: electronic particle counter
TEST CONCENTRATIONS
- Range finding study: 1 / 10 / 100 mg/L
- Test concentrations: 4.6 / 10 / 22 / 46 / 100 mg/L - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 46 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydolysis products
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 46 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- growth rate
- Details on results:
- - Exponential growth in the control (for algal test): yes
- Observation of abnormalities (for algal test): no - Results with reference substance (positive control):
- Biological Results of K2Cr2O7:
Parameter Value 95% confidence interval
72h ErC50 0.91 mg/L 0.80 – 1.0 mg/L
72h EyC50 0.66 mg/L 0.46 – 0.95 mg/L
The 72h-EC50s of potassium dichromate were determined in a separate reference test. For the estimation of the 72h-EC50s of the positive control, the fits showed sufficient statistical correspondence of the data with the dose-response-equation. The values were within the range of the laboratory. - Reported statistics and error estimates:
- There were no inhibitory effects observed up to 46 mg/L in the test and therefore statistical analysis of the results was not required. (the highest treatment of 100 mg/Lwas excluded from the determination of the biological results because the pH value was significantly lower than in all other treatments
and the blank control. Therefore, the weakness of algal growth and its strongly scattering inhibition values is supposed to be the result from the very low pH.)
Any other information on results incl. tables
Table 1 Calculated Test item Concentrations
Nominal Concentration Test Item
|
Calculated Concentration Test Item t = 0 h
|
Calculated Concentration Test Item t = 72 h
|
% of Nominal concentration t = 0 h
|
% of Nominal concentration t = 72 h
|
mg/L |
mg/L |
mg/L |
% |
% |
Blank control |
-- |
-- |
-- |
-- |
4.6 |
3.4 |
4.7 |
75 |
101 |
10 |
8.8 |
9.8 |
88 |
98 |
22 |
20.1 |
21.0 |
92 |
96 |
46 |
43.3 |
44.0 |
94 |
96 |
100 |
96.3 |
98.0 |
96 |
98 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 72 h EC50 of > 46 mg/L, and a 72 h NOEC of 46 mg/L have been determined for the effects of the test substance on growth rate of Desmodesmus subspicatus. The results are expressed relative to nominal concentrations of the test substance. However, the substance is subject to rapid hydrolysis and under the test conditions it is therefore likely that exposure will have been to its hydrolysis products.
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