Registration Dossier
Registration Dossier
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EC number: 202-263-9 | CAS number: 93-62-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Three fasted female Fisher 344 rats received 2000 mg/kg of neat test material by single dose gavache. Clinical signs and mortality were observed.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Disodium 2-hydroxyethyliminodi(acetate)
- EC Number:
- 205-187-4
- EC Name:
- Disodium 2-hydroxyethyliminodi(acetate)
- Cas Number:
- 135-37-5
- Molecular formula:
- C6H11NO5.2Na
- IUPAC Name:
- disodium 2,2'-[(2-hydroxyethyl)imino]diacetate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2000 mg/kg b.v.
- No. of animals per sex per dose:
- 3 female
- Control animals:
- no
- Details on study design:
- Three fasted female Fisher 344 rats received 2000 mg/kg of neat test material by single dose gavache. Clinical signs and mortality were observed.
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 800 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- One animal died at test day 8
- Clinical signs:
- other: Various combinations of urine or fecal perineal soiling, decreased activity, red or clear periocular soiling, red perinasal soiling, arched back postures, pale eyes and moderate incoordination. All clinical signes for surviving animals resolved by the tes
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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