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EC number: 619-547-7 | CAS number: 211515-46-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- Januaiy 3 1,2007 to October 06,2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- - Commission Directive 92/69/EEC, Annex Part C, C.3: "Algal Inhibition Test", Official Journal of the European Communities No. L 3 83 A, dated December 29, 1992. - OECD Guideline for Testing of Chemicals, Section 2, No. 201: "Freshwater Alga and Cyanobacteria, Growth Inhibition Test", adopted March 23, 2006. - OECD Series on Testing and Assessment, No. 23, "Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures", December 15, 2000.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Version / remarks:
- and EU Method C.3 (Algal Inhibition test)
- Deviations:
- yes
- Remarks:
- In the 1:33 dilution (0.85 mg test item/l nominal) only 2 replicates could be used for the evaluation of the results due to contamination. No effect on the study is presumed.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- CAT - Acid chloride
- IUPAC Name:
- CAT - Acid chloride
- Details on test material:
- Name: CAT - Acid chloride
Certificate of Analysis Date: March 30,2006
Type: Active ingredient of a pharmaceutical
Aggregate State at Room Temperature: Liquid (according to BACON personnel)
Colour: Brown (according to BACON personnel)
Stability: Technical product: see expiry date
Expiry Date: July 03,2007
Storage: In original container, in the refrigerator (2-8 degree C), in the dark.
Safety Precautions: Routine safety and hygienic procedures.
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 31 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 31 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 31 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Yield
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 31 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 31 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 31 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Yield
- Duration:
- 72 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 31 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 31 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 31 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- other: Yield
Any other information on results incl. tables
Analytical Results:
At the start of the test 30% of the nominal test concentration was
found (mean value of the three highest test concentrations). This
calculation based on nominal test concentrations not considering the
fact that the test media were filtrated to remove the non-dissolved
part of the test item. Therefore, these reduced findings are not
surprising. In the aged test media 26% of the nominal value was
determined (mean value of the two highest test concentrations).
Thus, during the test period the algae were exposed to a mean of
28% of nominal (mean value of all measured test concentrations).
The results of the two highest concentrations (filtrate and one
dilution) are expressed in terms of mean measured concentrations of
the test item. For the three lowest concentrations, under the limit of
quantification, the concentration was calculated by multiplying the
nominal value with the overall mean recovery of all measured test
concentrations (28%).
TOC analysis cannot differ between test item and degradation
products (both of them contribute to the signal, which is evaluated).
However, for the calculation of the recovery rate this has not to be
considered.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The influence of CAT - Acid chloride on the growth of the
freshwater green algal species Desmodesmus subspicatus was
assessed in a static dose-response test.
Up to the highest concentration, a filtrate of 100 mg test item
corresponding to a mean measured concentration of 31 mg test
item no effects on yield, growth rate and biomass occurred.
The overall NOEC was determined to be 100 mg test item/l
corresponding to a mean measured concentration of 31 mg test
item/l, the overall LOEC was determined to be higher than 100 mg
test item/l corresponding to a mean measured concentration of 31 mg
test item/l. - Executive summary:
Title:
Toxicity of CAT - Acid chloride to Desmodesmus subspicatus in an
Algal Growth Inhibition Test
Guidelines/Recommendations:
- Commission Directive 92/69/EEC, Annex Part C, C.3: "Algal
Inhibition Test", Official Journal of the European Communities
No. L 3 83 A, dated December 29, 1992.
- OECD Guideline for Testing of Chemicals, Section 2, No. 201:
"Freshwater Alga and Cyanobacteria, Growth Inhibition Test",
adopted March 23, 2006.
- OECD Series on Testing and Assessment, No. 23, "Guidance
Document on Aquatic Toxicity Testing of Difficult Substances
and Mixtures", December 15, 2000.
Purpose:
The purpose of this test was to determine the inhibitory effect of the
test item CAT - Acid chloride on the growth of the freshwater green
algal species Desmodesmus subspicatus.
Exponentially growing cultures of this unicellular green algal
species were exposed to various concentrations of the test item
under defined conditions. The inhibition of growth in relation to
control cultures was determined over a test period of 72 hours, and
thus over several algal generations.
The test method of application and the test system are recommended
by the test guidelines and Desmodesmus subspicatus is one of the
recommended test species.
Since the test item is instable and insoluble in test water, it was
tested according to OECD No. 23 (Testing of Difficult Substances).
Therefore, the stock solution was stirred for 25 hours, in order to
make allowance for the water insolubility of the test item. The non-dissolved
part of the test item was afterwards removed by filtration.
Due to the instability of the test item, mainly the degradation
products were tested.
The purpose of the analytical part of this study was to measure the
dissolved part of the test item and/or its degradation products using
measurement of Total Organic Carbon (TOC) as sum parameter.
Test Concentrations:
Filtrate of nominal 100 mg test item/l and 1:3.2, l:l0, 1:33, and 1:105
dilutions of this filtrate (corresponding to mean measured values of
31, 7.8, 2.8, 0.85, 0.27 mg test item/l). Additionally, a control was
tested in parallel (test water without addition of the test item).
Analytical Method:
The test item was analysed using a TOC method.
Analytical Results:
At the start of the test 30% of the nominal test concentration was
found (mean value of the three highest test concentrations). This
calculation based on nominal test concentrations not considering the
fact that the test media were filtrated to remove the non-dissolved
part of the test item. Therefore, these reduced findings are not
surprising. In the aged test media 26% of the nominal value was
determined (mean value of the two highest test concentrations).
Thus, during the test period the algae were exposed to a mean of
28% of nominal (mean value of all measured test concentrations).
The results of the two highest concentrations (filtrate and one
dilution) are expressed in terms of mean measured concentrations of
the test item. For the three lowest concentrations, under the limit of
quantification, the concentration was calculated by multiplying the
nominal value with the overall mean recovery of all measured test
concentrations (28%).
TOC analysis cannot differ between test item and degradation
products (both of them contribute to the signal, which is evaluated).
However, for the calculation of the recovery rate this has not to be
considered.
Conclusion:
The influence ofCAT- Acid chloride on the growth of the
freshwater green algal species Desmodesmus subspicatus was
assessed in a static dose-response test.
Upto the highest concentration, a filtrate of 100 mg test item
corresponding to a mean measured concentration of 31 mg test
item no effects on yield, growth rate and biomass occurred.
The overall NOEC was determined to be 100 mg test item/l
corresponding to a mean measured concentration of 31 mg test
item/l, the overall LOEC was determined to be higher than 100 mg
test item/l corresponding to a mean measured concentration of 31mg
test item/l.
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