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EC number: 217-552-5 | CAS number: 1885-38-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation :
Cinnamyl nitrile was used as a test material to evaluate its skin irritation potential on human subjects by closed patch test.
It was applied in the concentration of 4% in petrolatum for 48 hrs in a closed patch test produced no skin reaction.
Cinnamyl nitrile did not resulted any skin reaction when tested on human subjects. Hence, Cinnamyl nitrile can be considered as not irritation on human skin.
Eye irritation:
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the ocular irritation potential was estimated forCinnamyl nitrile. It was estimated thatCinnamyl nitrilewas not irritating to eye of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To evaluate skin irritation potential of Cinnamonitrile on human subjects.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- IUPAC: Cinnamonitrile
CAS No:1885-38-7
EC No: 217-552-5
Commen name: Cinnamyl Nitrile
Molecular formula : C9H7N
Molecular weight : 129.161 g/mol
substance type: organic
InChI: 1S/C9H7N/c10-8-4-7-9-5-2-1-3-6-9/h1-7H/b7-4+
Smiles :N#C\C=C\c1ccccc1
Physical state: colorless- yellow liquid - Details on test system:
- No data available
- Species:
- other: Human
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- other: petrolatum
- Controls:
- not specified
- Amount / concentration applied:
- 4% in petrolatum
- Duration of treatment / exposure:
- 48 hrs
- Observation period:
- 48 hrs
- Number of animals:
- Not specified
- Details on study design:
- Not specified
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No dermal reaction was observed on human skin
- Interpretation of results:
- other: Not irritant
- Conclusions:
- Cinnamyl nitrile did not resulted any skin reaction when tested on human subjects. Hence, Cinnamyl nitrile can be considered as not irritation on human skin.
- Executive summary:
Cinnamyl nitrile was used as a test material to evaluate its skin irritation potential on human subjects by closed patch test.
It was applied in the concentration of 4% in petrolatum for 48 hrs in a closed patch test produced no skin reaction.
Cinnamyl nitrile did not resulted any skin reaction when tested on human subjects. Hence, Cinnamyl nitrile can be considered to be not irritation on human skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is predicted using OECD QSAR toolbox version 3.3 and QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction was done by using OECD QSAR toolbox v3.3
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of the test material: (E)-3-phenylprop-2-enenitrile
- IUPAC name: (E)-3-phenylprop-2-enenitrile
- Molecular formula: C9H7N
- Molecular weight: 129.161 g/mol
- Substance type: Organic
- Smiles: N#C\C=C\c1ccccc1
Physical state: colorless- yellow liquid - Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data available
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- not specified
- Duration of treatment / exposure:
- not specified
- Observation period (in vivo):
- not specified
- Details on study design:
- No data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- no indication of irritation.
- Interpretation of results:
- other: Not irritating
- Conclusions:
- Cinnamyl nitrile is considered to be non irritant to rabbit eye.
- Executive summary:
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the ocular irritation potential was estimated for Cinnamyl nitrile. It was estimated that Cinnamyl nitrile was not irritating to eye of rabbits.
Reference
Estimation
method: Takes mode value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
(((((((((((((((((((("a"
or "b" or "c" or "d" )
and ("e"
and (
not "f")
)
)
and ("g"
and (
not "h")
)
)
and "i" )
and "j" )
and "k" )
and ("l"
and (
not "m")
)
)
and "n" )
and ("o"
and (
not "p")
)
)
and ("q"
and (
not "r")
)
)
and ("s"
and (
not "t")
)
)
and ("u"
and (
not "v")
)
)
and ("w"
and (
not "x")
)
)
and ("y"
and (
not "z")
)
)
and ("aa"
and (
not "ab")
)
)
and ("ac"
and (
not "ad")
)
)
and ("ae"
and (
not "af")
)
)
and ("ag"
and (
not "ah")
)
)
and ("ai"
and (
not "aj")
)
)
and ("ak"
and "al" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Alkene AND Aryl AND Nitrile by
Organic Functional groups
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Alkene AND Aryl AND Nitrile AND
Overlapping groups by Organic Functional groups (nested)
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Acetylenic Carbon [#C] AND
Aromatic Carbon [C] AND Olefinic carbon [=CH- or =C<] by Organic
functional groups (US EPA)
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Aromatic compound by Organic
functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OECD
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Acylation OR Acylation >> Direct
Addition of an Acyl Halide OR Acylation >> Direct Addition of an Acyl
Halide >> Acyl halide OR Acylation >> Isocyanates and Isothiocyanates OR
Acylation >> Isocyanates and Isothiocyanates >> Isocyanates OR Acylation
>> P450 Mediated Activation to Isocyanates or Isothiocyanates OR
Acylation >> P450 Mediated Activation to Isocyanates or Isothiocyanates
>> Benzylamines-Acylation OR Acylation >> P450 Mediated Activation to
Isocyanates or Isothiocyanates >> Thioureas OR Michael addition OR
Michael addition >> P450 Mediated Activation of Heterocyclic Ring
Systems OR Michael addition >> P450 Mediated Activation of Heterocyclic
Ring Systems >> Furans OR Michael addition >> P450 Mediated Activation
of Heterocyclic Ring Systems >> Thiophenes-Michael addition OR Michael
addition >> P450 Mediated Activation to Quinones and Quinone-type
Chemicals OR Michael addition >> P450 Mediated Activation to Quinones
and Quinone-type Chemicals >> Alkyl phenols OR Michael addition >> P450
Mediated Activation to Quinones and Quinone-type Chemicals >> Arenes OR
Michael addition >> P450 Mediated Activation to Quinones and
Quinone-type Chemicals >> Hydroquinones OR Michael addition >> P450
Mediated Activation to Quinones and Quinone-type Chemicals >>
Methylenedioxyphenyl OR Michael addition >> P450 Mediated Activation to
Quinones and Quinone-type Chemicals >> Polycyclic (PAHs) and
heterocyclic (HACs) aromatic hydrocarbons-Michael addition OR Michael
addition >> Polarised Alkenes-Michael addition OR Michael addition >>
Polarised Alkenes-Michael addition >> Alpha, beta- unsaturated esters OR
Michael addition >> Polarised Alkenes-Michael addition >> Alpha, beta-
unsaturated ketones OR Schiff base formers OR Schiff base formers >>
Chemicals Activated by P450 to Glyoxal OR Schiff base formers >>
Chemicals Activated by P450 to Glyoxal >> Ethanolamines (including
morpholine) OR Schiff base formers >> Chemicals Activated by P450 to
Mono-aldehydes OR Schiff base formers >> Chemicals Activated by P450 to
Mono-aldehydes >> Benzylamines-Schiff base OR Schiff base formers >>
Direct Acting Schiff Base Formers OR Schiff base formers >> Direct
Acting Schiff Base Formers >> Mono aldehydes OR SN1 OR SN1 >> Carbenium
Ion Formation OR SN1 >> Carbenium Ion Formation >> Allyl benzenes OR SN1
>> Carbenium Ion Formation >> Polycyclic (PAHs) and heterocyclic (HACs)
aromatic hydrocarbons-SN1 OR SN1 >> Iminium Ion Formation OR SN1 >>
Iminium Ion Formation >> Aliphatic tertiary amines OR SN1 >> Nitrenium
Ion formation OR SN1 >> Nitrenium Ion formation >> Aromatic azo OR SN1
>> Nitrenium Ion formation >> Aromatic nitro OR SN1 >> Nitrenium Ion
formation >> Aromatic phenylureas OR SN1 >> Nitrenium Ion formation >>
Primary (unsaturated) heterocyclic amine OR SN1 >> Nitrenium Ion
formation >> Primary aromatic amine OR SN1 >> Nitrenium Ion formation >>
Secondary aromatic amine OR SN1 >> Nitrenium Ion formation >> Tertiary
(unsaturated) heterocyclic amine OR SN1 >> Nitrenium Ion formation >>
Tertiary aromatic amine OR SN1 >> Nitrenium Ion formation >> Unsaturated
heterocyclic azo OR SN2 OR SN2 >> Direct Acting Epoxides and related OR
SN2 >> Direct Acting Epoxides and related >> Epoxides OR SN2 >>
Episulfonium Ion Formation OR SN2 >> Episulfonium Ion Formation >>
1,2-Dihaloalkanes OR SN2 >> Episulfonium Ion Formation >> Mustards OR
SN2 >> P450 Mediated Epoxidation OR SN2 >> P450 Mediated Epoxidation >>
Coumarins OR SN2 >> P450 Mediated Epoxidation >> Thiophenes-SN2 OR SN2
>> P450 Mediated Sulfoxidation OR SN2 >> P450 Mediated Sulfoxidation >>
Thioureas-SN2 OR SN2 >> SN2 at an sp3 Carbon atom OR SN2 >> SN2 at an
sp3 Carbon atom >> Aliphatic halides OR SN2 >> SN2 at an sp3 Carbon atom
>> Phosphates by DNA binding by OECD
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Non binder, without OH or NH2
group by Estrogen Receptor Binding
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Moderate binder, NH2 group OR
Moderate binder, OH grooup OR Non binder, impaired OH or NH2 group OR
Non binder, MW>500 OR Non binder, non cyclic structure OR Strong binder,
NH2 group OR Strong binder, OH group OR Very strong binder, OH group OR
Weak binder, NH2 group OR Weak binder, OH group by Estrogen Receptor
Binding
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as No superfragment by
Superfragments ONLY
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Bioavailable by Lipinski Rule
Oasis ONLY
Domain
logical expression index: "k"
Similarity
boundary:Target:
N#CC=Cc1ccccc1
Threshold=20%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Alkene AND Aryl AND Nitrile by
Organic Functional groups
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as Acetoxy OR Acid anhydride OR
Acridone/ Acridinimine OR Acrylamide OR Acrylate OR Alcohol OR Aldehyde
OR Aliphatic Amine, primary OR Aliphatic Amine, secondary OR Alkane,
branched with tertiary carbon by Organic Functional groups
Domain
logical expression index: "n"
Similarity
boundary:Target:
N#CC=Cc1ccccc1
Threshold=80%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain
logical expression index: "o"
Referential
boundary: The
target chemical should be classified as No alert found by Respiratory
sensitisation
Domain
logical expression index: "p"
Referential
boundary: The
target chemical should be classified as Michael Addition OR Michael
Addition >> Polarised alkenes OR Michael Addition >> Polarised alkenes
>> Indigotine and related OR Pro-Michael Addition OR Pro-Michael
Addition >> Pro-quinone and related OR Pro-Michael Addition >>
Pro-quinone and related >> Phenylenediamines OR Pro-SN2 OR Pro-SN2 >>
Pro-ring opening SN2 OR Pro-SN2 >> Pro-ring opening SN2 >> Vinyl
benzenes OR Pro-SN2 >> Pro-SN2 at chlorine OR Pro-SN2 >> Pro-SN2 at
chlorine >> N-Phenylacetamides by Respiratory sensitisation
Domain
logical expression index: "q"
Referential
boundary: The
target chemical should be classified as Non-Metals by Groups of elements
Domain
logical expression index: "r"
Referential
boundary: The
target chemical should be classified as Alkali Earth OR Halogens OR
Metalloids OR Metals OR Transition Metals by Groups of elements
Domain
logical expression index: "s"
Referential
boundary: The
target chemical should be classified as Stable form by Tautomers unstable
Domain
logical expression index: "t"
Referential
boundary: The
target chemical should be classified as Conjugated ketoamine(scy) -
1,5-H shift OR Imine - amine form(5-membered ring) - 1,3-H shift OR
Imine form - 1,3-H shift OR Thiolactim form by Tautomers unstable
Domain
logical expression index: "u"
Referential
boundary: The
target chemical should be classified as Not categorized by Repeated dose
(HESS)
Domain
logical expression index: "v"
Referential
boundary: The
target chemical should be classified as 3-Methylcholantrene
(Hepatotoxicity) Alert OR Aliphatic amines (Mucous membrane irritation)
Rank C OR Allyl esters (Hepatotoxicity) Rank A OR Amineptine
(Hepatotoxicity) Alert OR Aromatic hydrocarbons (Liver enzyme induction)
Rank C OR Benzene/ Naphthalene sulfonic acids (Less susceptible) Rank C
OR Benzenesulfonamides (Toxicity to urinary system) Rank B OR
Organophosphates (Neurotoxicity) Rank A OR Phenyl phoshates (Lipodosis
of adrenocortial) Rank C OR Phthalate esters (Testicular toxicity) Rank
C OR Tamoxifen (Hepatotoxicity) Alert OR Thiocarbamates/Sulfides
(Hepatotoxicity) No rank by Repeated dose (HESS)
Domain
logical expression index: "w"
Referential
boundary: The
target chemical should be classified as Aromatic compound by Organic
functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "x"
Referential
boundary: The
target chemical should be classified as Carbonyl compound by Organic
functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "y"
Referential
boundary: The
target chemical should be classified as Aromatic compound by Organic
functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "z"
Referential
boundary: The
target chemical should be classified as CO2 derivative (general) OR
Cyanate OR Dialkylether by Organic functional groups, Norbert Haider
(checkmol)
Domain
logical expression index: "aa"
Referential
boundary: The
target chemical should be classified as Aromatic compound by Organic
functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "ab"
Referential
boundary: The
target chemical should be classified as Alkylarylether OR Amine OR Anion
by Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "ac"
Referential
boundary: The
target chemical should be classified as Aromatic compound by Organic
functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "ad"
Referential
boundary: The
target chemical should be classified as Carbonic acid derivative by
Organic functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "ae"
Referential
boundary: The
target chemical should be classified as Aromatic compound by Organic
functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "af"
Referential
boundary: The
target chemical should be classified as Sulfonic acid by Organic
functional groups, Norbert Haider (checkmol)
Domain
logical expression index: "ag"
Referential
boundary: The
target chemical should be classified as Acetylenic Carbon [#C] AND
Aromatic Carbon [C] AND Olefinic carbon [=CH- or =C<] by Organic
functional groups (US EPA)
Domain
logical expression index: "ah"
Referential
boundary: The
target chemical should be classified as Aliphatic Nitrogen, one aromatic
attach [-N] by Organic functional groups (US EPA)
Domain
logical expression index: "ai"
Referential
boundary: The
target chemical should be classified as Acetylenic Carbon [#C] AND
Aromatic Carbon [C] AND Olefinic carbon [=CH- or =C<] by Organic
functional groups (US EPA)
Domain
logical expression index: "aj"
Referential
boundary: The
target chemical should be classified as Aromatic Nitrogen by Organic
functional groups (US EPA)
Domain
logical expression index: "ak"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 1.49
Domain
logical expression index: "al"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 2.95
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
In different studies, Cinnamonitrile has been investigated for potential for dermal irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits along with human data for target chemical Cinnamonitrile and its structurally similar read across substance Cinnamyl formate (104-65-4).
Various studies forCinnamonitrilewere summarized in Food and Cosmetics Toxicology, Volume 12, Issues 7–8, December 1974, Page 897; to assess the dermal irritation potential in humans and rabbits.
Cinnamonitrileapplied at full strength to intact or abraded rabbit underocclusion caused slight o moderate irritation. Also, when tested on human subjects at 4% in petrolatum in a 48-hr closed-patch test,Cinnamonitrileproduced no irritation.
Even though rabbit study indicates thatCinnamyl nitrile is slightly to moderately irritating to rabbit skin but human data concludes that it is not irritating to human skin. Since, in the rabbit study skin was exposed to higher concentration ofCinnamyl nitrilethan the normal use, there exists a possibility ofCinnamyl nitrilebeing of not irritating to rabbit skin at lower concentrations. So,Cinnamyl nitrilecan be considered to be not irritating to skin.
These experimental studies are also supported by the estimated data.
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the dermal irritation potential was estimated for Cinnamyl nitrile. It was estimated that Cinnamyl nitrile was not irritating to skin of rabbits.
Skin irritation effects were also estimated by four different models i.e, Battery, Leadscope, SciQSAR and CASE Ultra used within Danish QSAR database forCinnamyl nitrile. Based on estimation, No severe skin irritation effects were known whenCinnamyl nitrilewas exposed to rabbit skin.
The experimental and estimated data are in agreement with each other; substantiate the claim thatCinnamyl nitrileis indeed not irritating to skin.
These results are further supported by the experimental study summarized inFood and Chemical Toxicology 45 (2007) S1–S23 for the structurally similar read across substance Cinnamyl formate (104-65-4). Cinnamyl formate was used as a test material for maximization pre-test to evaluate it’s skin irritation potential on 5 male volunteers . The test material was used in the concentration of 4% in petrolatum ,
No skin reactions were observed. Cinnamyl formate was considered to be not irritating to human skin.
Based on the available data for the target as well as it read across substances and applying the weight of evidence approach,it can be concluded that Cinnamyl nitrilewas not irritating to skin. Itcan be classified under the category “Not Classified” as per CLP regulation
Eye irritation :
In different studies, Cinnamonitrile has been investigated for potential for ocular irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits along with human data for target chemical Cinnamonitrile and its structurally similar read across substances Cinnamyl formate (104-65-4) and Methyl cinnamate (103-26-4).
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the ocular irritation potential was estimated for Cinnamyl nitrile. It was estimated that Cinnamyl nitrile was not irritating to eye of rabbits.
The above predicted data was supported by experimental study conducted by Food and Chemical Toxicology, 50 (2012) S402-S406 for the structurally similar read across substance Benzyl formate (104-57-4).
Benzyl formate (undiluted) was evaluated for eye irritation in four female SPF alibino rabbits. A dose volume of 0.1 ml was instilled into one eye. The untreated eye of each animal served as a control. Observations were made at 1, 48, 72 h and 7 days after treatment. At 24 h after dosing, corneal opacity was scattered or diffuse on more than one quarter but less than one half of the cornea. Application of fluorescein confirmed this finding. The conjunctivawere diffuse, crimson red with individual vessels not easily discernible, swelling was noted as well as an abnormal discharge. At 48 h after dosing, the scattered or diffuse area of opacity was still noted on one quarter or less of the cornea, even after instillation of fluorescein. The conjunctiva was diffusely red; the individual vessels were not easily discernible and abnormal swelling was present. At 72 h after dosing, the conjunctival vessels were injected and following the instillation of fluorescein a scattered or diffuse area of opacity on one quarter or less of the cornea was noted. By 7 days after dosing the animals were free of any signs of eye irritation
Benzyl formate when applied on the eye of SPF albino rabbits and observed for 7 days gave ocular reactions which were cleared by day 7. Hence , Benzyl formate is considered to be non eye irritant.
The above experimental data was further supported by study conducted by Food and Chemical Toxicology 45 (2007) S1–S23 for structurally similar read across substanceMethyl cinnamate (103-26-4).
Methyl cinnamate was used as test material for evaluating its eye irritation potential on rabbits
The test material was applied ocularly in the concentration 100% ,
No ocular reaction were observed . Hence, Methyl cinnamate can be considered non eye irritant on rabbit eye.
Based on the available data for the target as well as it read across substances and applying weight of evidences,it can be concluded that Cinnamyl nitrile was not irritating to eye; and itcan be classified under the category “Not Classified” as per CLP regulation.
Justification for classification or non-classification
Based on the available data for the target as well as it read across substances and applying weight of evidences,it can be concluded that Cinnamyl nitrile was not irritating to skin and eye; and it can be classified under the category “Not Classified” as per CLP regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.