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EC number: 230-819-0 | CAS number: 7328-91-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test substance is corrosive to skin and eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- Mean body weight: 3 kg
The animals were offered a standardized animal laboratory diet. - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- ca. 1 ml
- Duration of treatment / exposure:
- 3 min
- Observation period:
- 8 d
- Number of animals:
- 2
- Details on study design:
- Application area: 2.5 x 2.5
Application site: back of the rabbits
The test substance was washed off with Lutrol. - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 3 min
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- other: severe, not relocatable necrosis after days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 3 min
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- other: leather-like necrosis after 8 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 3 min
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- The skin findings were macroscopically confirmed by the pathologist.
- Interpretation of results:
- Category 1A (corrosive) based on GHS criteria
- Conclusions:
- The test substance is corrosive to skin.
Reference
Animal No. |
3 min |
1 day |
2 days |
8 days |
||||
Erythema |
Edema |
Erythema |
Edema |
Erythema |
Edema |
Erythema |
Edema |
|
1 |
3 e |
2 |
4 Np |
3 |
4 Np |
2 |
4 Nh |
2 |
2 |
3 e |
2 |
4 Np |
2 |
4 Np |
2 |
4 Nl |
2 |
e: extending beyond the area of exposure
N: necrosis (p: parchment-like; h: hard/displacable; l: leathery)
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- according to Fed. Reg. 38, No. 187, § 1500.42; 1973 (Draize Test)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- A standardized animal laboratory diet was used.
Mean body weight: 2.8 kg - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of the same animal
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 8 d
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- scoring according to Draize
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- other: after 48 h, the eye was clotty (purulence) and thus could not be estimated
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- other: after 48 h, the eye was clotty (purulence) and thus could not be estimated
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- other: after 48 h, the eye was clotty (purulence) and thus could not be estimated
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- The test substance is corrosive to eyes.
Reference
Readings |
Animal |
Cornea |
Iris |
Conjunctiva |
Symptoms |
|||
op |
ar |
red |
sw |
|
||||
24 h |
1 |
3 |
4 |
1 |
2 |
2 |
|
Pupil contracted, nictitation membrane, mucosa reddish brown, blood |
2 |
3 |
4 |
1 |
2 |
2 |
|
||
3 |
3 |
4 |
1 |
2 |
2 |
|
||
48 h |
1 |
* |
* |
* |
* |
3 |
|
|
2 |
* |
* |
* |
* |
3 |
|
|
|
3 |
4 |
4 |
* |
2 |
3 |
|
|
|
72 h |
1 |
* |
* |
* |
* |
3 |
|
|
2 |
* |
* |
* |
* |
3 |
|
|
|
3 |
4 |
4 |
* |
2 |
3 |
|
|
|
8 days |
1 |
* |
* |
* |
* |
3 |
|
|
2 |
* |
* |
* |
* |
3 |
|
|
|
3 |
* |
* |
* |
* |
3 |
|
|
*eye was clotty, could not be estimated
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
In a primary dermal irritation study two Vienna White rabbits were dermally exposed to 1.0 mL of undiluted test substance for 3 min under an occlusive dressing (BASF AG, 1979). Animals were then observed for 72 hours. The animals showed severe erythema and edema. According to the results the substance is corrosive to skin.
Eye irritation
In a primary eye irritation study (Draize test) 0.1 mL of the unchanged test substance was applied to the eyes of three New Zealand White (BASF AG, 1979). The animals were observed for 8 day. After 24 hours the eyes showed severe corneal opacity and inflammation of the iris. After 48 hours the eyes were clotty, iris score, conjunctiva score and corneal opacity could not be estimated. Based on the results it is concluded that the test substance is corrosive to eyes.
Justification for classification or non-classification
Based on the results of the skin and eye corrosion testing, the test item is classified and labelled as skin corrosive cat. 1A (H314) and eye damaging cat. 1 (H318) according to Regulation (EC) No 1272/2008 (CLP).
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