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EC number: 235-166-5 | CAS number: 12108-13-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study, similar to OECD 401 with sufficient information on methodology and result for assessment.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Remarks:
- Information on body weight and complete description of necropsy results is missing.
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Tricarbonyl(methylcyclopentadienyl)manganese
- EC Number:
- 235-166-5
- EC Name:
- Tricarbonyl(methylcyclopentadienyl)manganese
- Cas Number:
- 12108-13-3
- Molecular formula:
- C9H7MnO3
- IUPAC Name:
- tricarbonyl(methyl-η5-cyclopentadienyl)manganese
- Details on test material:
- - Name of test material (as cited in study report): methylcyclopentadienyl manganese tricarbonyl
- Physical state: Orange liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 180-230 g
- Fasting period before study: No data
- Housing: No data
- Diet : ad libitum
- Water : ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12 hrs / 12 hrs
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- mmt was given in corn oil (3 ml/kg)
- Doses:
- 30, 47.4, 75 and 118 mg/kg.
- No. of animals per sex per dose:
- 5 male rats per dose.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations for mortality performed daily
- Necropsy of survivors performed: no data - Statistics:
- Student's t test was used for determination of statistical significance. The moving average interpolation method of Thompson and Weil (1952) was used to estimate the LD50.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 51.8 mg/kg bw
- Remarks on result:
- other: ± 10.9 (SD)
- Mortality:
- Yes, detailed information on table 1.
- Clinical signs:
- other: Not recorded.
- Gross pathology:
- Necroscopy of animals that died within 24 hrs after mmt dosing, showed grossly distended lungs with a blood-containing fluid.
- Other findings:
- - Potential target organs: lungs
Any other information on results incl. tables
Table 1 - Mortality in rats following administration of mmt
Dosea (mg/kg) |
Mortalityb/Dosed |
Length of survival Of animals dying |
30 |
0/5 |
|
47.4 |
2/5 |
2 – 3 days |
75 |
5/5 |
2 – 3 days |
118 |
4/5 |
<48 hr |
ammt doses given in corn oil (3 ml/kg) to rats weighting 190-210 g.
bCummulative mortality during 14 after dosing.
Table 2 - Effects of MMT on liver and lung
Treatment Groupa |
N |
Body wt (g) |
Lung wt x 10³/ Body wt |
GPT (units/ml) |
G-6-Pase (mg Pi/g Liver/20 min |
Hepatic Triglyceride (mg/g liver) |
A. Control |
7 |
198 ± 4 |
5.58 ± 0.21 |
34 ± 2 |
7.47 ± 0.70 |
5.29 ± 0.27 |
mmtb |
6 |
218 ± 12 |
11.95 ± 1.18c |
29 ± 1 |
8.96 ± 0.53 |
5.42 ± 0.98 |
mmt+PB |
7 |
210 ± 12 |
5.78 ± 0.30d |
133 ± 34d |
5.68 ± 0.52d |
5.94 ± 1.33 |
B. Control |
5 |
196 ± 3 |
6.52 ± 0.15 |
32 ± 2 |
14.32 ± 0.32 |
nd |
mmt |
5 |
189 ± 2 |
16.09 ± 3.52c |
36 ± 4 |
13.29 ± 0.94 |
nd |
ammt was administered po at a dose of 125 mg/kg in corn oil (3 ml/kg). Part A reports results (mean ± SE) obtained 24 h and part B 12 h after dosing with mmt. Rats were given Phenobarbital (60 mg/kg, ip) for 3 days.
bThese data are from 6 survivors of 14 treated animals.
cSignificantly different from control, p<0.05
dSignificantly different from mmt alone, p<0.05
eNot determined
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Acute oral toxicant category 3: H300 "Toxic if swallowed"..
- Conclusions:
- The oral LD50 for mmt in male rats was determined to be 51.8 mg/kg day.
- Executive summary:
In an acute oral toxicity study, groups of 5 male Sprague-Dawley rats were given a single oral dose of mmt in corn oil (3ml/kg) at doses of 30, 47.4, 75 and 118 mg/kg, and observed for 14 days. In a concurrent study, 125 mg/kg of mmt in corn oil (3 ml/kg) was administrated orally to rats with or without pre-treatment with phenobarbital (PB) to assess effects on body and lung weight, GPT, G-6-Pase and hepatic triglyceride. Effects were measured at 12 and 24 hours after treatment.
Necropsy of examination of animals which died within 24 hours after mmt showed lungs grossly distended with a blood-containing fluid.
For the study of the effect of mmt on liver and lung, the following were observed:
- Rats without PB pre-treatment exhibited a significant increase of lung weight (the weight doubled in relation to the control);
- Rats pretreated with PB had lung weights comparable to the control;
- The concentration of GPT increased greatly in rats pretreated with PB in relation to both control and mmt-treated rats.
- No significant elevation in GPT in mmt rats without PB pretreatment.
As elevated concentrations of GPT is a potential indicator of liver damage, the results indicate that that Phenobarbital pre-treatment may shift the toxicity of mmt from the lungs to the liver.
The male rat oral LD50 was determined to be 51.8 ± 10.9 mg/kg
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