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EC number: 500-133-9 | CAS number: 56641-05-5 1 - 2.5 moles ethoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Phenol, ethoxylated, esters with acrylic acid
- EC Number:
- 500-133-9
- EC Name:
- Phenol, ethoxylated, esters with acrylic acid
- Cas Number:
- 56641-05-5
- Molecular formula:
- C13H16O4 (PHEA-2) - C23H36O9 (PHEA-7)
- IUPAC Name:
- 2-phenoxyethyl prop-2-enoate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Miramer M142, Lot. No.: 0082301
- Expiration date of the lot/batch: 30 April 2001
- Purity test date: Not specified
- Purity: >95%
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature in the dark.
- Stability under test conditions: NA
- Solubility and stability of the test substance in the solvent/vehicle: NA
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: NA
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: administred as supplied by sponsor.
- Preliminary purification step (if any):NA
- Final dilution of a dissolved solid, stock liquid or gel: NA
- Final preparation of a solid:NA
FORM AS APPLIED IN THE TEST (if different from that of starting material)
Exposure scenarios
OTHER SPECIFICS: NA
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Weight range beteen 2.8 and 3.8kg bw, Age at least 10weeks prior first treatment. Housed individually in metal cages. Standard laboratory diet, SQC Rabbit Diet and drinking water ad libitum. Temperature 17-21 C, relative humidity 30-70%. Air exchange per hour was not specified. 12 hour/12 hours Light/dark cycle
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml was applied under 25*25mm gauze pads to each intact skin site on each animal.
- Duration of treatment / exposure:
- 3 minutes, 60 minutes and 4 hours
- Observation period:
- On the day of exposure ( 3 minutres and one hour), 24, 48 and 72 hours
- Number of animals:
- 3 animals
- Details on study design:
- TEST SITE
- Area of exposure: 25 mm x 25 mm
- % coverage: not specified
- Type of wrap if used: Semi occlusive: Porous gauze pads and Elastoplast elastic adhesive dressing.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): warm water 34-37 oC
- Time after start of exposure: three minutes, one hour and four hours
OBSERVATION TIME POINTS
(indicate if minutes, hours or days) three minutes, one hour and four hours.
SCORING SYSTEM:
- Method of calculation: Primary irritation index (PII) was calculated from the erythema and oedema scores.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 1.2
- Reversibility:
- fully reversible within: 96 hours
- Irritant / corrosive response data:
- Well-defiend erythema with very slight-to-slight oedema was observed in two animals from approximately one hour after bandage removal following the four hours exposure. Reaction had resolved in both animals by Day 4 (96h). No dermal irritation was observed in the remaining animals throughout the study.
- Other effects:
- No signs of toxicity or ill health
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: US CPSC / US FDA
- Conclusions:
- The skin irritation potential of M142 was tested using semi-occlusive application for four hours in three Rabbits (one male and two females) according to OECD test guideline 404. Dermal irritation was observed in two of three animals 4 hours after application. The primary irritation index (PII) was calculated to be 1.2. Based on the present test M142 was not subject for classification as a skin irritating substance.
- Executive summary:
The skin irritation potential of M142 was tested using semi-occlusive application for four hours in three Rabbits (one male and two females) according to OECD test guideline 404.
Dermal observations were made three minutes, one hour, four hours, 24, 48 and 72 hours after removal of the semi-occlusive dressing. Well-defined dermal irritation was observed in two of three animals 4 hours after application. The primary irritation index (PII) was calculated to be 1.2. Mean values of erythema and oedema were below the values triggering CLP classification. Hence, based on the present test M142 was not subject for classification as a skin irritating substance.
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