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Diss Factsheets
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EC number: 230-811-7 | CAS number: 7328-17-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Oct 1996 - Jan 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to the relevant guidance on dermal toxicity, OECD 402.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- SR256, Lot# HCE0995; 2,(2-ethoxyethoxy)ethylacrylate
- IUPAC Name:
- SR256, Lot# HCE0995; 2,(2-ethoxyethoxy)ethylacrylate
- Test material form:
- other: clear colorless liquid
- Details on test material:
- Lot/batch No.: HCE 0995
- Specific gravity: 1.02
- purity: 94% (GC)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals were received from Ace Animals, Boyertown, PA. Following the quarantine period of at least one week, five healthy male and five non-pregnant, nulliparous, healthy female were randomly assigned to the treatment groups.The pretest body weight range was 2.0-2.5 kg for males and 2.0-2.6 kg for females. the w eight variation of the animals used did not exceed +/- 20% of the mean body weight.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The test artice was used as received. It had been applied to the clipped site by a syringe at 1000 mg/kg bw and 2000 mg/kg bw. The doses were based upon the sample weight as calculated from the specific gravity. The test article was applied on the top of a four layered surgical gauze patch measurig 10x15cm. *Gentle pressure was applied to the gauze to aid in the distribution of the test substance over the prepared site. The torso was wrapped with plastic which was secured with non-irritating tape. The test article remained in contact with the skin for 24 hours at which time the wrappings were removed. Residual test article was removed by gentle washing with distilled water.
- Duration of exposure:
- 24 hrs
- Doses:
- 1000 mg/kg bw and 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: The animals were observed 1, 2 and 4 hours postdose and once daily for 14 days for toxicity and pharmacological effects. The animals were observed twice daily for 14 days for mortality. The test sites were scored for dermal irritation at 24 hrs postdose and on days 7 and 14 using the numerical Dreize scoring code.
- Frequency of weighing: Body weights were recorded pretest, weekly and at death, or termination of the survivors.
- Necropsy of survivors performed: All animals were examined for gross pathology. Abnormal tissues were preserved in 10% buffered formalin for possible future microscopic examination. - Statistics:
- None: the estimate of the LD50 was made based on the survivals during the study.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 - < 2 000 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Dose group 1000 mg/kg bw
females 0/5
males 0/5
Dose group 2000 mg/kg bw
females 1/5
males 3/5 - Clinical signs:
- other: Lethargy, soiling on the anogenital area, ataxia, flaccid muscle tone, emaciation, wetness of the nose/mouth and breathing difficulties.
- Gross pathology:
- Animals died during the study revealed abnormalities of the lungs, dosed site, liver and gastrointestinal tract as well as wetness of the nose/mouth and anogenital area, emacination and soiling of the anogenital area. Necropsy of survivors revealed abnormalities of the treated skin, kidneys, liver, lungs, intestines, peritoneal cavity and soiling of the anogenital area.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 is greater than 2000 mg/kg body weight for female rabbits
The LD50 is in the range of 1000 - 2000 mg/kg bw for male rabbits.
Fullfil the criteria for classification as Acute Tox 4; H312 - Executive summary:
An OECD 402 study was perfomed with rabbits (5 males, 5 females) at dose levels of 1000 mg/kg bw and 2000 mg/kg bw.
The LD50 was greater than 2000 mg/kg body weight for female rabbits
The LD50 was in the range of 1000 - 2000 mg/kg bw for male rabbits.
The LD50 value for male rabbits fullfils the criteria for classification as Acute Tox 4; H312.
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