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EC number: 225-245-2 | CAS number: 4736-60-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: US Federal Hazardous Substances Control Act
- Version / remarks:
- Code of Federal Regulations, Titel 16, Chapter II, 1977
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
- Remarks:
- study performed prior to implementation of GLP
Test material
- Reference substance name:
- Ethyltriphenylphosphonium iodide
- EC Number:
- 225-245-2
- EC Name:
- Ethyltriphenylphosphonium iodide
- Cas Number:
- 4736-60-1
- Molecular formula:
- C20H20IP
- IUPAC Name:
- ethyltriphenylphosphonium iodide
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Albino rabbits (no further data)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the counter lateral eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 mg per eye - Duration of treatment / exposure:
- single instillation without washing
- Observation period (in vivo):
- Reading time points: 24, 48 and 72 hours after instillation
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): not rinsed
SCORING SYSTEM: according to Draize 1959
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1, #3, #4, #5, #6
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 3.33
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- animal: #1, #2, #3, #4, #5, #6
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #1, #2, #3, #4, #5
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: #6
- Time point:
- 24/48/72 h
- Score:
- 2.66
- Max. score:
- 3
- Irritation parameter:
- chemosis score
- Basis:
- animal: #6
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1, #3
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal: #5
- Time point:
- 24/48/72 h
- Score:
- 3.33
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal: #2, #4
- Time point:
- 24/48/72 h
- Score:
- 3.66
- Max. score:
- 4
- Irritant / corrosive response data:
- Within 24 hours following application, signs of irritation included moderate to severe corneal opacity, mild iritis, and severe conjunctivitis in all rabbits. Blanching of the conjunctivae and nictitating membrane was noted in two rabbits during the observation period. Irritative effects were relatively unchanged during the 72-hour observation period.
Any other information on results incl. tables
Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test
Score at time point / Reversibility |
Cornea |
Iris |
Conjunctivae |
Chemosis |
Discharge | Other |
Max. score: 4 |
Max. score: 2 |
Max. score: 3 |
Max. score: 4 |
Max. score: 3 |
||
24 h |
2/3/2/2/2/2 |
1/1/1/1/1/1 |
3/3/3/3/3/3 |
3/3/3/3/3/2 |
3/3/3/3/3/3 |
A |
48 h |
2/3/2/2/2/2 |
1/1/1/1/1/1 |
3/3/3/3/3/3 |
3/4/3/4/3/2 |
3/3/3/3/3/3 |
A |
72 h |
2/4/2/2/2/2 |
1/B/1/1/1/1 |
3/3/3/3/3/2 |
3/4/3/4/4/2 |
3/3/3/3/3/2 |
|
Average 24h, 48h, 72h |
2/3,33/2/2/2/2/2 |
1/1/1/1/1/1 |
3/3/3/3/3/2,66 |
3/3,66/3/3,66/3,33/2 |
||
Area effected |
4/4/4/4/4/4 |
|||||
Reversibility*) |
n |
n |
n |
n |
*) Reversibility: c. = completely reversible; n.c. = not completely reversible; n. = not reversible
B=Unable to score due to swelling, A = In two animals entire nictitating membrane and diffuse areas of conjunctivae blanched (whitened).
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Ethyltriphenylphosphonium iodide induced moderate to severe corneal opacity, mild iritis, severe conjunctivitis and blanching of the conjunctivae and nictitating membrane. The effects were non reversible within the observation period.
Classification is based on effects on the cornea, iris and conjunctiva calculated as mean scores following grading at 24, 48 and 72 hours after instillation of the test material, in consideration of reversibility.
According to the criteria of REGULATION (EC) No 1272/2008 as well as the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations, Ethyltriphenylphosphonium iodide has the potential to seriously damage the eyes and is classified in Category 1 (irreversible effects on the eye).
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