Reaction mass of 3,6,9-trioxaundecane-1,11-diol and 2,2'-oxydiethanol and 2,2'-(ethylenedioxy)diethanol and 3,6,9,12-tetraoxatetrade

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

supporting study

Study period:

Prior to May 1976

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: early study report; short study description

Justification for type of information:

Read across is based on the category approach. Please refer to attached category document.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Principles of method if other than guideline:

according to BASF-internal standards

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3,6,9-trioxaundecane-1,11-diol

EC Number:

203-989-9

EC Name:

3,6,9-trioxaundecane-1,11-diol

Cas Number:

112-60-7

Molecular formula:

C8H18O5

IUPAC Name:

2,2'-[oxybis(ethane-2,1-diyloxy)]diethanol

Test material form:

not specified

Details on test material:

purity about 90%

Test animals

Species:

rabbit

Strain:

Vienna White

Details on test animals or test system and environmental conditions:

Body weight male rabbit: 3.48 kg
Body weight female rabbit: 3.49

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

other: untreated skin of the same animal

Amount / concentration applied:

0.5 g

Duration of treatment / exposure:

20 h

Observation period:

Readings after 24 hours and 8 days

Number of animals:

2

Details on study design:

The test substance was applied to a 2.5 x 2.5 cm application site of white Vienna rabbits for 20 h under occlusive conditions. The skin was either intact or abraded. After the application time, the skin was washed with water which may have contained a mild detergent. Animals were observed for 8 days and skin changes were observed on working days. Findings were recorded after 1 min, 5 min, 15 min and 20 hours and at the end of the observation period. Findings were graded as described in OECD test guideline 404.

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 24 h

Score:

0

Irritant / corrosive response data:

No irritation was observed.

Other effects:

After 20-hour exposure a slight reddening (ear) was observed, which was reversible within 8 days.

Any other information on results incl. tables

No additional information available.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

No dermal irritation was noted at the application site following 20 hour exposure to the test material.

Executive summary:

The dermal irritation potential was examined in a pre-guideline study. No dermal irritation was noted at the application site following 20 hour exposure to the test material.