Registration Dossier
Registration Dossier
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EC number: 233-343-1 | CAS number: 10124-56-8
Toxicity to reproduction
Administrative data
- Endpoint:
- three-generation reproductive toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Justification for type of information:
- A scientific review.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of Sodium Metaphosphate, Sodium Trimetaphosphate, and Sodium Hexametaphosphate
- Author:
- Reviewed by the Cosmetic Ingredient Review Expert Panel.
- Year:
- 2 001
- Bibliographic source:
- International Journal of Toxicology, p 75-89.
- Reference Type:
- review article or handbook
- Title:
- Summaries of toxicological data: Toxicity studies on phosphates .
- Year:
- 1 964
- Bibliographic source:
- Food Cosmet. Toxicol. 2:147–154.
Materials and methods
- Principles of method if other than guideline:
- Three generations of rats were reared and maintained on diets containing 0.5% Sodium Hexametaphosphate. Two litters per generation were examined.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium metaphosphate
- EC Number:
- 233-343-1
- EC Name:
- Sodium metaphosphate
- Cas Number:
- 10124-56-8
- Molecular formula:
- Na6O18P6
- IUPAC Name:
- hexasodium 2,4,6,8,10,12-hexaoxocyclohexaphosphoxane-2,4,6,8,10,12-hexakis(olate)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Details on exposure:
- Three generations of rats were reared and maintained on diets containing 0.5% Sodium Hexametaphosphate or 0.05% Sodium
Trimetaphosphate. Two litters per generation were examined. - Details on mating procedure:
- The rats (16 females and 8males per group) were mated when the rats were each 100 days old.
Results and discussion
Any other information on results incl. tables
Diet containing 0.05% Sodium Hexametaphosphate had no effect on fertility, litter size, growth, or survival of offspring. Third generation rats had no evident abnormal organ weights or microscopic changes.
Applicant's summary and conclusion
- Conclusions:
- Diet containing 0.05% Sodium Hexametaphosphate had no effect on fertility, litter size, growth, or survival of offspring. Third generation rats had no evident abnormal organ weights or microscopic changes.
- Executive summary:
Three generations of rats were reared and maintained on diets containing 0.5% Sodium Hexametaphosphate.
Sodium Hexametaphosphate had no effect on fertility, litter size, growth, or survival of offspring. Third generation rats had no evident abnormal organ weights or microscopic changes.
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