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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental start date: 19 August 2015 Experimental completion date: 24 December 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- The water solubility at 20.0 ± 0.5 °C was determined at a nominal loading rate of 10% using the flask method, designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 59.5 other: g/L as Test Item
- Conc. based on:
- other: using a nominal loading rate of 10%
- Remarks:
- Monoalkyl phosphate
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 3.5
- Remarks on result:
- other: .The water solubility of the test item has been determined at 20.0 ± 0.5 °C using a nominal loading rate of 10%
- Water solubility:
- ca. 2.97 other: g/L As Component
- Conc. based on:
- other: using a nominal loading rate of 10%
- Remarks:
- Monoalkyl phosphate
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 3.5
- Remarks on result:
- other: The water solubility of the test item has been determined at 20.0 ± 0.5 °C using a nominal loading rate of 10%
- Water solubility:
- 1.61 other: g/L as Test Item
- Conc. based on:
- other: using a nominal loading rate of 10%
- Remarks:
- Dialkyl pyrophosphate
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 3.5
- Remarks on result:
- other: The water solubility of the test item has been determined at 20.0 ± 0.5 °C using a nominal loading rate of 10%
- Water solubility:
- ca. 0.515 other: g/L as Component
- Conc. based on:
- other: using a nominal loading rate of 10%
- Remarks:
- Dialkyl pyrophosphate
- Incubation duration:
- 20 h
- Temp.:
- 20 °C
- pH:
- 3.5
- Remarks on result:
- other: The water solubility of the test item has been determined at 20.0 ± 0.5 °C using a nominal loading rate of 10%
- Water solubility:
- 3.29 other: g/L as Test Item
- Conc. based on:
- other: using a nominal loading rate of 10%
- Remarks:
- Dialkyl phosphate
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 3.5
- Remarks on result:
- other: The water solubility of the test item has been determined at 20.0 ± 0.5 °C using a nominal loading rate of 10%
- Water solubility:
- ca. 1.58 other: g/L as Component
- Conc. based on:
- other: using a nominal loading rate of 10%
- Remarks:
- Dialkyl phosphate
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 3.5
- Remarks on result:
- other: .The water solubility of the test item has been determined at 20.0 ± 0.5 °C using a nominal loading rate of 10%
- Water solubility:
- 0.041 other: g/L as Test Item
- Conc. based on:
- other: using a nominal loading rate of 10%
- Remarks:
- Trialkly pyrophosphate
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 3.5
- Remarks on result:
- other: The water solubility of the test item has been determined at 20.0 ± 0.5 °C using a nominal loading rate of 10%
- Water solubility:
- 0.006 other: g/L as Component
- Conc. based on:
- other: using a nominal loading rate of 10%
- Remarks:
- Trialkly pyrophosphate
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 3.5
- Remarks on result:
- other: The water solubility of the test item has been determined at 20.0 ± 0.5 °C using a nominal loading rate of 10%
- Details on results:
- please see below
- Conclusions:
- The water solubility of the test item has been determined at 20.0 ± 0.5 °C using a nominal loading rate of 10% and the results are as follows:
Table 11
Component of Test Item Concentration (g/L)
As Test Item As Component
Monoalkyl phosphate 59.5 ~2.97
Dialkyl pyrophosphate 1.61 ~0.515
Dialkyl phosphate 3.29 ~1.58
Trialkly pyrophosphate 4.14 x 10-2 ~6.21 x 10-3
Although, additional testing demonstrated that the water solubility of the components was loading rate dependent. - Executive summary:
The water solubility at 20.0 ± 0.5 °C was determined at a nominal loading rate of 10% using the flask method, designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. The results are as follows:
Table 1
Component of Test Item
Concentration (g/L)
As Test Item
As Component
Monoalkyl phosphate
59.5
~2.97
Dialkyl pyrophosphate
1.61
~0.515
Dialkyl phosphate
3.29
~1.58
Trialkly pyrophosphate
4.14 x 10-2
~6.21 x 10-3
Although, additional testing demonstrated that the water solubility of the components was loading rate dependent.
Reference
PreliminaryTest
The preliminary estimates of water solubility at 20.0 ± 0.5 °C for the four components are shown in the table below. The solution had a pH of 3.5.
Table 4
Peak |
Component of Test Item |
Concentration (g/L) |
|
As Test Item |
As Component |
||
1 |
Monoalkyl phosphate |
49.1 |
~2.45 |
2 |
Dialkyl pyrophosphate |
1.45 |
~0.463 |
3 |
Dialkyl phosphate |
4.19 |
~0.201 |
4 |
Trialkly pyrophosphate |
0.123 |
~1.85 x 10-2 |
MainTest
Typical chromatography is presented in the attached Appendix 1.
The mean peak areas relating to the standard and sample solutions are shown in the following tables:
Table 5 - Sample 1
Solution |
Mean Peak Area |
|||
Peak 1 |
Peak 2 |
Peak 3 |
Peak 4 |
|
Standard 1.03 mg/L |
8.743 x103 |
6.970 x104 |
1.145 x105 |
2.126 x104 |
Standard 5.16 mg/L |
4.259 x104 |
3.371 x105 |
5.814 x105 |
1.426 x105 |
Standard 10.3 mg/L |
7.887 x104 |
6.779 x105 |
1.055 x106 |
3.785 x105 |
Standard 20.6 mg/L |
1.899 x105 |
1.475 x106 |
2.201 x106 |
8.307 x105 |
Standard 25.2 mg/L |
2.064 x105 |
1.634 x106 |
2.467 x106 |
9.584 x105 |
Standard 31.0 mg/L |
3.245 x105 |
2.192 x106 |
3.236 x106 |
1.262 x106 |
Standard 41.3 mg/L |
4.291 x105 |
2.709 x106 |
3.961 x106 |
1.555 x106 |
Standard 51.6 mg/L |
6.140 x105 |
3.574 x106 |
5.097 x106 |
2.185 x106 |
Sample 1A |
2.521 x105 |
2.112 x106 |
1.696 x106 |
2.806 x105 |
Sample 1B |
3.659 x105 |
2.142 x106 |
1.729 x106 |
2.617 x105 |
Table 6 – Sample 2
Solution |
Mean Peak Area |
|||
Peak 1 |
Peak 2 |
Peak 3 |
Peak 4 |
|
Standard 1.03 mg/L |
9.406 x103 |
8.059 x104 |
1.224 x105 |
2.195 x104 |
Standard 5.16 mg/L |
4.259 x104 |
3.371 x105 |
5.814 x105 |
1.426 x105 |
Standard 10.3 mg/L |
8.776 x104 |
7.387 x105 |
1.174 x106 |
3.011 x105 |
Standard 20.6 mg/L |
1.899 x105 |
1.475 x106 |
2.201 x106 |
8.307 x105 |
Standard 25.2 mg/L |
2.614 x105 |
1.844 x106 |
2.794 x106 |
9.455 x105 |
Standard 31.0 mg/L |
3.245 x105 |
2.192 x106 |
3.236 x106 |
1.262 x106 |
Standard 41.3 mg/L |
5.157 x105 |
3.064 x106 |
4.484 x106 |
1.769 x106 |
Standard 51.6 mg/L |
6.140 x105 |
3.574 x106 |
5.097 x106 |
2.185 x106 |
Sample 2A |
2.492 x105 |
2.186 x106 |
1.728 x106 |
2.787 x105 |
Sample 2B |
4.152 x105 |
2.261 x106 |
1.799 x106 |
2.792 x105 |
Table 7 – Sample 3
Solution |
Mean Peak Area |
|||
Peak 1 |
Peak 2 |
Peak 3 |
Peak 4 |
|
Standard 1.03 mg/L |
9.406 x103 |
8.059 x104 |
1.224 x105 |
2.195 x104 |
Standard 5.16 mg/L |
5.161 x104 |
4.044 x105 |
6.986 x105 |
1.421 x105 |
Standard 10.3 mg/L |
8.776 x104 |
7.387 x105 |
1.174 x106 |
3.011 x105 |
Standard 20.6 mg/L |
2.307 x105 |
1.678 x106 |
2.546 x106 |
7.413 x105 |
Standard 25.2 mg/L |
2.614 x105 |
1.844 x106 |
2.794 x106 |
9.455 x105 |
Standard 31.0 mg/L |
3.796 x105 |
2.503 x106 |
3.743 x106 |
1.241 x106 |
Standard 41.3 mg/L |
5.157 x105 |
3.064 x106 |
4.484 x106 |
1.769 x106 |
Standard 51.6 mg/L |
7.071 x105 |
4.098 x106 |
5.859 x106 |
2.225 x106 |
Sample 3A |
3.604 x105 |
2.647 x106 |
1.995 x106 |
2.832 x105 |
Sample 3B |
2.553 x105 |
2.685 x106 |
2.035 x106 |
2.720 x105 |
Typical calibration curves from which the sample concentrations were interpolated are shown in the atached Figure 1 to Figure 4.
The concentration (g/L) of four test item components in the sample solutions at 20.0 ± 0.5 ºC are shown in the following table:
Table 8
Sample Number |
Concentration (g/L) |
Solution pH |
|||
Peak 1 |
Peak 2 |
Peak 3 |
Peak 4 |
||
1 |
62.9 |
1.57 |
3.31 |
3.86 x 10-2 |
3.7 |
2 |
61.2 |
1.54 |
3.15 |
4.19 x 10-2 |
3.8 |
3 |
54.3 |
1.73 |
3.41 |
4.38 x 10-2 |
3.7 |
Mean |
59.5 |
1.61 |
3.29 |
4.14 x 10-2 |
|
The mean sample concentrations as weight of test item and approximate concentrations corrected for the approximate percentage composition of the components are shown in the following table:
Table 9
Peak |
Component of Test Item |
Concentration (g/L) |
|
As Test Item |
As Component |
||
1 |
Monoalkyl phosphate |
59.5 |
~2.97 |
2 |
Dialkyl pyrophosphate |
1.61 |
~0.515 |
3 |
Dialkyl phosphate |
3.29 |
~1.58 |
4 |
Trialkly pyrophosphate |
4.14 x 10-2 |
~6.21 x 10-3 |
Description of key information
The water solubility at 20.0 ± 0.5 °C was determined at a nominal loading rate of 10% using the flask method, designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. The results are as follows:
Table 1
Component of Test Item |
Concentration (g/L) |
|
As Test Item |
As Component |
|
Monoalkyl phosphate |
59.5 |
~2.97 |
Dialkyl pyrophosphate |
1.61 |
~0.515 |
Dialkyl phosphate |
3.29 |
~1.58 |
Trialkly pyrophosphate |
4.14 x 10-2 |
~6.21 x 10-3 |
Although, additional testing demonstrated that the water solubility of the components was loading rate dependent.
Key value for chemical safety assessment
- Water solubility:
- 2.97 g/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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