Registration Dossier
Registration Dossier
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EC number: 201-381-8 | CAS number: 81-85-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- QSAR prediction for skin sensitisation (SciQSAR)
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2017-10-16
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Please refer to the OPRF and QMRF report attached in section 'Attached Justification'.
Data source
Reference
- Reference Type:
- other: QSAR tool
- Title:
- SciMatics SciQSAR version of commercial CASE Ultra model A33 for allergic contact dermatitis (ACD) in guinea pig and human, Danish QSAR Group at DTU Food.
- Author:
- MultiCASE Inc.23811 Chagrin Blvd Ste 305, Beachwood, OH, 44122, USA
- Year:
- 2 014
- Bibliographic source:
- This is a categorical (Q)SAR model based on calculated molecular descriptors, and if available the modeller’s own or third party descriptors or measured endpoints can be imported and used as descriptors.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- A prediction was performed with the QSAR model SciQSAR.
Test material
- Reference substance name:
- 6-bromo-3-methyl-3H-dibenz[f,ij]isoquinoline-2,7-dione
- EC Number:
- 201-381-8
- EC Name:
- 6-bromo-3-methyl-3H-dibenz[f,ij]isoquinoline-2,7-dione
- Cas Number:
- 81-85-6
- Molecular formula:
- C17H10BrNO2
- IUPAC Name:
- 6-bromo-3-methyl-3H-naphtho[1,2,3-de]quinoline-2,7-dione
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Parameter:
- other: QSAR
- Remarks on result:
- positive indication of skin sensitisation
Any other information on results incl. tables
Pyridon is predicted to be sensitising by the skin sensitization model SciQSAR.
Applicant's summary and conclusion
- Interpretation of results:
- other: data not sufficient for classification
- Conclusions:
- Pyridon is predicted to be sensitising.
- Executive summary:
Skin sensitization of Pyridon was predicted with the Skin Sensitization model SciQSAR, which is implemented in the 'Danish QSAR Database'. Pyridon is predicted to be sensitising. This prediction is reliable, it was generated by a scientifically valid model and lies within the applicability domain (please refer also to the QPRF and QMRF attached in the section 'Attached Justification').
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