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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 601-639-3 | CAS number: 119851-28-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
Concerning the skin sensitisation of the TS two in vivo studies were performed.
Both studies comply with the OECD Principles of Good Laboratory Practice (GLP).
Under the experimental conditions employed in the 1988 study, significant differences between the test group and the vehicle-treated controls were seen after intradermal challenge application, i.e. when the skin barrier was intentionally by-passed.
4/20 animals were positive at the 24 hours evaluation after epidermal challenge. However, these reactions after epidermal challenge were only of slight degree and in one animal faded away within 24 hours. Therefore, the slight reactions observed after epidermal challenge are considered not to be allergic.
The negative results upon epidermal challenge demonstrate that, in artificially sensitised guinea-pigs, exposure of the intact skin to the test article does not provoke contact dermatitis.
In the 1991 study moderate allergenic potency was concluded after the second challenge. According to the EEC classification applied the TS is considered to be a sensitizer.
There is no obvious reason explaining the different test results in the two studies. Both studies are in accordance with OECD guideline or similar to OECD guideline in force at time of study conduction. Further on both studies are quality checked and in compliance with the Principles of Good Laboratory Practice. Therefore they should be assessed as reliable without restriction (Klimisch 1, GLP guideline study).The purity of both test items was different and there may be different impurities which lead to a sensitising effect. This can not finally be assessed.
Migrated from Short description of key information:
Concerning the skin senisitisation of the TS two in vivo studies were performed. Both can be assessed as reliable
without restriction. However the results of the studies differ and lead to different classification.
According to the precautionary principle the TS should be classified and labelled.
Justification for classification or non-classification
According to the precautionary principle the TS should be regarded as a skin sensitizer and preliminary classified and labelled as such.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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